Sugi Predict

Sugi Predict / Compounds / SCHEMBL20375671

SCHEMBL20375671

SCHEMBL20375671

COP(=O)(OC)OCCCCNC(=O)Cc1cnc2c(CCO)cccc2c1-c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MTNR1A P48039 2/20 0.36
▸ PTPN1 P18031 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ LMNA P02545 2/20 0.35
▸ POLB P06746 1/20 0.35
▸ PPARG P37231 3/20 0.34
▸ NR1H2 P55055 3/20 0.34
▸ NR1H3 Q13133 3/20 0.34
▸ PPARD Q03181 1/20 0.34
▸ PPARA Q07869 1/20 0.34
▸ TERT O14746 2/20 0.34
▸ TAAR1 Q96RJ0 1/20 0.34
▸ KDM4E B2RXH2 3/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ CA12 O43570 1/20 0.34
▸ CA1 P00915 1/20 0.34
▸ CA2 P00918 1/20 0.34
▸ CA3 P07451 1/20 0.34
▸ CA4 P22748 1/20 0.34
▸ CA6 P23280 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18086330 0.92 TERT (0.39) MTNR1APTPN1HPGDLMNAPOLB
SCHEMBL22077955 0.91 HPGD (0.42) MTNR1APTPN1HPGDLMNAPOLB
SCHEMBL20216031 0.91 TERT (0.36) MTNR1APPARGNR1H2NR1H3PPARD
SCHEMBL22172455 0.88 TERT (0.40) MTNR1APPARGNR1H2NR1H3PPARD
SCHEMBL22404704 0.88 TERT (0.40) MTNR1APPARGNR1H2NR1H3TERT
SCHEMBL17954278 0.87 GAA (0.34) MTNR1APTPN1HPGDPPARGNR1H2
SCHEMBL17954246 0.87 TERT (0.37) MTNR1APTPN1PPARGNR1H2NR1H3
SCHEMBL17955294 0.86 TERT (0.39) PTPN1PPARGNR1H2NR1H3PPARD
SCHEMBL17381242 0.85 CA12 (0.41) MTNR1AHPGDPPARGNR1H2NR1H3
SCHEMBL20101129 0.85 MTNR1A (0.43) MTNR1AHPGDPPARGNR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210238602-A1 RNAi Agents And Compositions for Inhibiting Expression of Angiopoietin-Like 3 (ANGPTL3), And Methods Of Use SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT 2021-08-05 — — US disclosed
US-20210069337-A1 INTEGRIN TARGETING LIGANDS AND USES THEREOF SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT 2021-03-11 — — US disclosed
US-20200369613-A1 INTEGRIN LIGANDS AND USES THEREOF SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT 2020-11-26 — — US disclosed
US-10662427-B2 Compositions and methods for inhibiting gene expression of LPA Arrowhead Pharmaceuticals, Inc. (US) 2020-05-26 — — US disclosed
US-20180195070-A1 Compositions and Methods for Inhibiting Gene Expression of LPA Arrowhead Pharmaceuticals, Inc. 2018-07-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210238602-A1 RNAi Agents And Compositions for Inhibiting Expression of Angiopoietin-Like 3 (ANGPTL3), And Methods Of Use TEK, PLIN3, PNLIP MTNR1A 2145/4885PTPN1 1288/4885HPGD 3790/4885
US-20200369613-A1 INTEGRIN LIGANDS AND USES THEREOF ITGB6, ITGA6, ITGAV MTNR1A 3568/4885PTPN1 2551/4885HPGD 4754/4885
US-20210069337-A1 INTEGRIN TARGETING LIGANDS AND USES THEREOF ITGAV, ITGA5, ITGB5 MTNR1A 4335/4885PTPN1 3610/4885HPGD 4595/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.