Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | MAOB | P27338 | 7/20 | 0.35 |
| ▸ | MAOA | P21397 | 5/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8529340 | 0.79 | ALOX15 (0.41) | IDO1MAOBMAOAMEN1ALDH1A1 | |
| SCHEMBL20384525 | 0.78 | EPAS1 (0.46) | MAOBMAOARXFP1TDP1ALDH1A1 | |
| SCHEMBL15067807 | 0.76 | IDO1 (0.40) | IDO1MAOACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8528307 | 0.75 | CYP19A1 (0.42) | MAOBMAOADAO | |
| SCHEMBL20442961 | 0.73 | KDM4E (0.32) | KDM4E | |
| SCHEMBL7952409 | 0.72 | MAOA (0.52) | MAOBMAOACYP1A2NPSR1RXFP1 | |
| SCHEMBL20384329 | 0.72 | KDM4E (0.38) | IDO1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL23340738 | 0.71 | RXFP1 (0.46) | MAOBMAOACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16005244 | 0.70 | HTR2A (0.36) | IDO1RXFP1KDM4EMEN1ALDH1A1 | |
| SCHEMBL6816553 | 0.70 | MAOA (0.50) | MAOBMAOANPSR1RXFP1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110167939-B | Pyrrolo [2,3-c ] pyridine derivatives, preparation method and medical application thereof | 江苏豪森药业集团有限公司 | 2021-12-31 | — | — | CN | disclosed |
| CN-110198941-B | Pyrrolopyridine N-oxide derivative and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-09-28 | — | — | CN | disclosed |
| WO-2018137655-A1 | PYRROLO-PYRIDINES N-OXIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 江苏豪森药业集团有限公司 | 2018-08-02 | — | — | WO | disclosed |
| WO-2018130174-A1 | PYRROLO[2,3-C]PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | 江苏豪森药业集团有限公司 | 2018-07-19 | — | — | WO | disclosed |