SCHEMBL20397476

SCHEMBL20397476

CC(C)C(N)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(C(=O)NC(Cc1c[nH]cn1)C(=O)NC(C(=O)NC(Cc1c[nH]cn1)C(=O)O)C(C)C)C(C)C

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FNTA P49354 4/20 0.37
FNTB P49356 4/20 0.37
ANPEP P15144 2/20 0.37
LNPEP Q9UIQ6 2/20 0.37
CASP3 P42574 4/20 0.37
CASP7 P55210 2/20 0.37
BACE1 P56817 3/20 0.36
DPP3 Q9NY33 1/20 0.35
CTSD P07339 1/20 0.34
REN P00797 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20397445 1.00 FNTA (0.37) FNTAFNTBANPEPLNPEPCASP3
SCHEMBL31049654 0.96 CTSD (0.38) FNTAFNTBANPEPLNPEPCASP3
SCHEMBL29881377 0.93 CTSD (0.35) FNTAFNTBANPEPLNPEPCASP3
SCHEMBL30738394 0.93 BACE1 (0.41) CASP3CASP7BACE1CTSD
SCHEMBL29853431 0.93 BACE1 (0.41) CASP3CASP7BACE1CTSD
SCHEMBL79320 0.92 ACE (0.36)
SCHEMBL78173 0.92 ACE (0.36)
SCHEMBL78174 0.92 ACE (0.36)
SCHEMBL29697029 0.91 ANPEP (0.34) ANPEPLNPEPBACE1DPP3
SCHEMBL30974548 0.90 BACE1 (0.35) FNTAFNTBCASP3CASP7BACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210000972-A1 NANOPARTICLES FOR SUSTAINED OPHTHALMIC DRUG DELIVERY AND METHODS OF USE NEWPORT SCIENTIFIC, INC. 2021-01-07 US disclosed
WO-2018140580-A1 NANOPARTICLES FOR SUSTAINED OPHTHALMIC DRUG DELIVERY AND METHODS OF USE 2C TECH CORP. (US) 2018-08-02 WO disclosed
US-20180207293-A1 NANOPARTICLES FOR SUSTAINED OPHTHALMIC DRUG DELIVERY AND METHODS OF USE NEWPORT SCIENTIFIC, INC. 2018-07-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180207293-A1 NANOPARTICLES FOR SUSTAINED OPHTHALMIC DRUG DELIVERY AND METHODS OF USE UACA, CRYAA, CRYAB FNTA 3228/4885FNTB 3508/4885ANPEP 761/4885
US-20210000972-A1 NANOPARTICLES FOR SUSTAINED OPHTHALMIC DRUG DELIVERY AND METHODS OF USE CHRNA1, CHRNB1, NPY1R FNTA 4333/4885FNTB 4056/4885ANPEP 2274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.