Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 12/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 12/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 12/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8222390 | 0.79 | ADRA1D (0.64) | ADRA1DADRA1AADRA1BALDH1A1MAPT | |
| SCHEMBL18668985 | 0.78 | ALDH1A1 (0.70) | ALDH1A1MAPTTSHRALOX15HSD17B10 | |
| SCHEMBL17866111 | 0.76 | KMT2A (0.56) | ADRA1DADRA1AADRA1BALDH1A1MAPT | |
| SCHEMBL10928006 | 0.75 | ALOX15 (0.56) | ADRA1DADRA1AADRA1BALDH1A1MAPT | |
| SCHEMBL2040789 | 0.75 | CA12 (0.55) | ADRA1DADRA1AADRA1BALDH1A1MAPT | |
| SCHEMBL5958272 | 0.75 | CASP3 (0.59) | ADRA1DADRA1AADRA1BALDH1A1MAPT | |
| SCHEMBL3029864 | 0.75 | KMT2A (0.59) | ALDH1A1MAPTLMNAMAPK1TSHR | |
| SCHEMBL2780391 | 0.73 | HDAC7 (0.60) | ADRA1DADRA1AADRA1BALDH1A1MAPT | |
| SCHEMBL7918934 | 0.72 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNAMAPK1KMT2A | |
| SCHEMBL11485668 | 0.72 | MAPT (0.52) | ADRA1DADRA1AADRA1BALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516419-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011079102-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2011-06-30 | — | — | WO | disclosed |