SCHEMBL20404

SCHEMBL20404

O=C1c2ccccc2C(=O)N1CCN1CCNCC1

nearest known ligand 0.62

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 6/20 0.55
KDM1A O60341 1/20 0.54
MAOB P27338 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29564155 1.00 HTR1A (0.55) HTR1AKDM1AMAOB
SCHEMBL26634553 0.91 HTR1A (0.62) HTR1AMAOB
SCHEMBL6970401 0.90 HTR1A (0.64) HTR1AKDM1AMAOB
SCHEMBL829254 0.90 HTR1A (0.64) HTR1AMAOB
SCHEMBL6964152 0.90 HTR1A (0.64) HTR1AKDM1AMAOB
SCHEMBL7083797 0.89 HTR1A (0.65) HTR1AMAOB
Hydrochloric Acid SCHEMBL829918 0.89 HTR1A (0.62) HTR1AMAOB
Hydrochloric Acid SCHEMBL2558698 0.89 HTR1A (0.62) HTR1AMAOB
Hydrochloric Acid SCHEMBL2557258 0.87 HTR1A (0.63) HTR1AMAOB
SCHEMBL23164620 0.87 HTR1A (0.67) HTR1AMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10456473-B2 Lipid compositions ARBUTUS BIOPHARMA CORPORATION (CA) 2019-10-29 US claimed
US-20180104342-A1 LIPID COMPOSITIONS ARBUTUS BIOPHARMA CORPORATION (CA) 2018-04-19 US claimed
CN-102421417-A Lipid composition ALNYLAM PHARMACEUTICALS INC 2012-04-18 CN claimed
EP-2416760-A1 LIPID COMPOSITIONS Alnylam Pharmaceuticals, Inc. (US) 2012-02-15 EP claimed
WO-2010129709-A1 LIPID COMPOSITIONS ALNYLAM PHARMACEUTICALS, INC. (US) 2010-11-11 WO claimed
EP-1277771-A2 Living polymerisation process for the production of sequenced polymers using functional radical initiators Atofina (FR) 2003-01-22 EP claimed
EP-0911350-A1 Fabrication process for copolymers of controlled architecture via the use of functional radical initiators in a living radical polymerisation, and initiator compositions and corresponding copolymers ELF ATOCHEM S.A. (FR) 1999-04-28 EP claimed
US-12023383-B2 Lipid compositions ARBUTUS BIOPHARMA CORPORATION (CA) 2024-07-02 US disclosed
US-12023383-B2 Lipid compositions ARBUTUS BIOPHARMA CORPORATION (CA) 2024-07-02 US disclosed
US-20240066129-A1 LIPID COMPOSITIONS ARBUTUS BIOPHARMA CORPORATION (US) 2024-02-29 US disclosed
US-20240066129-A1 LIPID COMPOSITIONS ARBUTUS BIOPHARMA CORPORATION (US) 2024-02-29 US disclosed
US-20240066129-A1 LIPID COMPOSITIONS ARBUTUS BIOPHARMA CORPORATION (US) 2024-02-29 US disclosed
CN-114524781-A Lipid composition 阿布特斯生物制药公司 2022-05-24 CN disclosed
WO-2010129709-A1 LIPID COMPOSITIONS ALNYLAM PHARMACEUTICALS, INC. (US) 2010-11-11 WO disclosed
WO-2010129709-A1 LIPID COMPOSITIONS ALNYLAM PHARMACEUTICALS, INC. (US) 2010-11-11 WO disclosed
EP-1288236-A2 Production process for copolymers with controlled architecture with the aid of functional radical initiators in a living radical polymerisation Atofina (FR) 2003-03-05 EP disclosed
EP-1277771-A2 Living polymerisation process for the production of sequenced polymers using functional radical initiators Atofina (FR) 2003-01-22 EP disclosed
EP-0911350-A1 Fabrication process for copolymers of controlled architecture via the use of functional radical initiators in a living radical polymerisation, and initiator compositions and corresponding copolymers ELF ATOCHEM S.A. (FR) 1999-04-28 EP disclosed
US-5318970-A Cyclooxygenase, lipoxygenase inhibitors TAIHO PHARMACEUTICAL CO., LTD. (JP) 1994-06-07 US disclosed
EP-0549797-A1 ISOXAZOLE COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND MEDICINAL USE THEREOF TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) 1993-07-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180104342-A1 LIPID COMPOSITIONS SGMS1, LIPA, SGMS2 HTR1A 3997/4885KDM1A 4762/4885MAOB 3705/4885
US-10456473-B2 Lipid compositions SGMS1, LIPA, SGMS2 HTR1A 3997/4885KDM1A 4762/4885MAOB 3705/4885
US-20240066129-A1 LIPID COMPOSITIONS SGMS1, SGMS2, LIPA HTR1A 4268/4885KDM1A 4781/4885MAOB 3749/4885
US-12023383-B2 Lipid compositions SGMS1, SGMS2, LIPA HTR1A 4268/4885KDM1A 4781/4885MAOB 3749/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.