Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | APAF1 | O14727 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20406087 | 0.83 | MPO (0.43) | FEN1PDE10ADRD1GCKRAB9A | |
| SCHEMBL20406079 | 0.83 | PDE10A (0.44) | PDE10ADRD1GCKRAB9AMEN1 | |
| SCHEMBL580112 | 0.81 | MEN1 (0.56) | PDE10ADRD1GCKALDH1A1RAB9A | |
| SCHEMBL20406280 | 0.80 | PDE10A (0.40) | PDE10ADRD1ALDH1A1RAB9AMEN1 | |
| SCHEMBL20406071 | 0.79 | PDE10A (0.44) | PDE10ADRD1GCKRAB9AMEN1 | |
| SCHEMBL3878940 | 0.79 | PDE10A (0.43) | PDE10ADRD1HSP90AA1GCKALDH1A1 | |
| SCHEMBL4008329 | 0.78 | PDE10A (0.51) | PDE10ADRD1ALDH1A1MEN1KMT2A | |
| SCHEMBL15923259 | 0.77 | LMNA (0.52) | FEN1PDE10AALDH1A1MAPT | |
| SCHEMBL20406088 | 0.77 | PDE10A (0.42) | PDE10ADRD1GCKRAB9A | |
| SCHEMBL20406324 | 0.76 | PDE10A (0.38) | PDE10ADRD1GCKALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351533-A1 | BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 2018-07-25 | — | — | EP | disclosed |