SCHEMBL20412084

SCHEMBL20412084

FC(F)(F)c1ccc2c(c1)N(CCCN1CCC(N3CCCC3)CC1)c1ccccc1S2

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 12/20 0.79
LMNA P02545 6/20 0.71
MAPT P10636 6/20 0.71
SMN1; SMN2 Q16637 5/20 0.71
CYP3A4 P08684 4/20 0.71
MAPK1 P28482 4/20 0.71
TP53 P04637 3/20 0.71
RAD52 P43351 3/20 0.71
ALDH1A1 P00352 2/20 0.71
CYP1A2 P05177 2/20 0.71
ABCB1 P08183 2/20 0.71
HTR1A P08908 2/20 0.71
ADRA2A P08913 2/20 0.71
ADORA3 P0DMS8 2/20 0.71
CYP2D6 P10635 2/20 0.71
CHRM1 P11229 2/20 0.71
DRD2 P14416 2/20 0.71
ADRA2B P18089 2/20 0.71
ADRA2C P18825 2/20 0.71
NFKB1 P19838 2/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31673764 1.00 FPR2 (0.79) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL30703686 0.99 FPR2 (0.81) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL20412094 0.99 FPR2 (0.81) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL31673755 0.98 FPR2 (0.79) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL20412107 0.98 FPR2 (0.79) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL20412115 0.97 FPR2 (0.81) FPR2LMNAMAPTSMN1; SMN2CYP3A4
Cyclophenazine SCHEMBL351628 0.92 FPR2 (0.77) FPR2LMNAMAPTSMN1; SMN2CYP3A4
Cyclophenazine SCHEMBL29710907 0.92 FPR2 (0.77) FPR2LMNAMAPTSMN1; SMN2CYP3A4
SCHEMBL20427426 0.91 FPR2 (0.72) FPR2LMNAMAPTSMN1; SMN2CYP3A4
Cyclophenazine SCHEMBL122920 0.91 LMNA (0.77) FPR2LMNAMAPTSMN1; SMN2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230330095-A1 PHARMACEUTICAL COMPOSITION FOR ANTI-CANCER COMPRISING NUPR1 ISOFORM A INHIBITOR SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION (KR) 2023-10-19 US claimed
EP-4260861-A1 PHARMACEUTICAL COMPOSITION FOR ANTI-CANCER COMPRISING NUPR1 ISOFORM A INHIBITOR Seoul National University R & DB Foundation (KR) 2023-10-18 EP claimed
US-10035795-B1 Phenothiazine derivatives having CaM inhibitory activity KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2018-07-31 US claimed
US-20230330095-A1 PHARMACEUTICAL COMPOSITION FOR ANTI-CANCER COMPRISING NUPR1 ISOFORM A INHIBITOR SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION (KR) 2023-10-19 US disclosed
EP-4260861-A1 PHARMACEUTICAL COMPOSITION FOR ANTI-CANCER COMPRISING NUPR1 ISOFORM A INHIBITOR Seoul National University R & DB Foundation (KR) 2023-10-18 EP disclosed
US-10035795-B1 Phenothiazine derivatives having CaM inhibitory activity KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2018-07-31 US disclosed
US-10035795-B1 Phenothiazine derivatives having CaM inhibitory activity KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2018-07-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230330095-A1 PHARMACEUTICAL COMPOSITION FOR ANTI-CANCER COMPRISING NUPR1 ISOFORM A INHIBITOR NUP205, NUP50, NUP188 FPR2 4687/4885LMNA 236/4885MAPT 2789/4885
US-10035795-B1 Phenothiazine derivatives having CaM inhibitory activity CALM1, CAMK4, CAMK1 FPR2 3304/4885LMNA 2841/4885MAPT 655/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.