Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.49 |
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | HTT | P42858 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RNF4 | P78317 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8906002 | 0.80 | MEN1 (0.69) | NPC1RAB9AHTTALDH1A1PAX8 | |
| SCHEMBL21193581 | 0.76 | RAB9A (0.51) | NPC1RAB9AHTTALDH1A1PAX8 | |
| SCHEMBL2931129 | 0.71 | ALDH1A1 (0.66) | NPC1RAB9AHTTALDH1A1PAX8 | |
| SCHEMBL991685 | 0.71 | RAB9A (0.72) | NPC1RAB9AHTTALDH1A1PAX8 | |
| SCHEMBL5451636 | 0.70 | NPC1 (0.67) | NPC1RAB9AHTTALDH1A1PAX8 | |
| SCHEMBL11069887 | 0.70 | ALDH1A1 (0.44) | NPC1RAB9AHTTALDH1A1PAX8 | |
| SCHEMBL18706686 | 0.69 | RIPK1 (0.47) | NPC1RAB9AHTTALDH1A1KMT2A | |
| SCHEMBL1877690 | 0.67 | KMT2A (0.51) | NPC1RAB9AHTTALDH1A1KMT2A | |
| SCHEMBL10686463 | 0.67 | KMT2A (0.75) | NPC1RAB9AHTTALDH1A1PAX8 | |
| SCHEMBL16403718 | 0.67 | RIPK1 (0.46) | NPC1RAB9AHTTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3573980-A1 | COMPOUNDS | GlaxoSmithKline Intellectual Property Management Limited (GB) | 2019-12-04 | — | — | EP | disclosed |
| WO-2018137619-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-08-02 | — | — | WO | disclosed |