Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20429028 | 0.88 | CYP11B2 (0.56) | CYP11B2ALDH1A1LMNATSHRL3MBTL1 | |
| SCHEMBL18871844 | 0.87 | CYP11B2 (0.51) | CYP11B2ALDH1A1LMNATSHRL3MBTL1 | |
| SCHEMBL18871784 | 0.85 | TP53 (0.49) | CYP11B2ALDH1A1LMNATSHRL3MBTL1 | |
| SCHEMBL27265658 | 0.84 | CYP11B2 (0.48) | CYP11B2ALDH1A1LMNATSHRL3MBTL1 | |
| SCHEMBL18871821 | 0.82 | PDK1 (0.50) | CYP11B2ALDH1A1LMNATSHRL3MBTL1 | |
| SCHEMBL18871768 | 0.79 | CYP11B1 (0.58) | CYP11B2ALDH1A1LMNATSHRL3MBTL1 | |
| SCHEMBL18871779 | 0.79 | ALDH1A1 (0.47) | CYP11B2ALDH1A1LMNATSHRL3MBTL1 | |
| SCHEMBL25700505 | 0.78 | RORC (0.44) | CYP11B2ALDH1A1LMNATSHRL3MBTL1 | |
| SCHEMBL18871976 | 0.78 | LMNA (0.58) | CYP11B2ALDH1A1LMNATSHRL3MBTL1 | |
| SCHEMBL23063895 | 0.77 | CYP11B2 (0.58) | CYP11B2ALDH1A1LMNACYP11B1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168213-B1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2018-08-01 | — | — | EP | disclosed |