Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21276451 | 1.00 | PTGS1 (0.39) | PTGS1PTGS2OPRM1OPRD1OPRK1 | |
| SCHEMBL26231801 | 0.92 | AKT1 (0.36) | PTGS1PTGS2OPRM1OPRD1OPRK1 | |
| SCHEMBL26231883 | 0.92 | AKT1 (0.36) | PTGS1PTGS2OPRM1OPRD1OPRK1 | |
| SCHEMBL29633571 | 0.88 | PTGS1 (0.53) | PTGS1PTGS2HTTHPGDSMN1; SMN2 | |
| SCHEMBL22538847 | 0.85 | PTGS1 (0.39) | PTGS1PTGS2OPRM1OPRD1OPRK1 | |
| SCHEMBL23691617 | 0.84 | ALDH1A1 (0.35) | HTTHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL24990014 | 0.84 | ALDH1A1 (0.35) | HTTHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL23331904 | 0.82 | OPRM1 (0.36) | PTGS1PTGS2OPRM1OPRD1OPRK1 | |
| SCHEMBL14463606 | 0.82 | PTGS1 (0.35) | PTGS1PTGS2OPRM1OPRD1OPRK1 | |
| SCHEMBL22618132 | 0.81 | PTGS1 (0.38) | PTGS1PTGS2OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4148044-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | ImmunoGen, Inc. (US) | 2023-03-15 | — | — | EP | disclosed |
| US-20230039161-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. | 2023-02-09 | — | — | US | disclosed |
| US-20210230114-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. | 2021-07-29 | — | — | US | disclosed |
| US-20210139510-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. | 2021-05-13 | — | — | US | disclosed |
| US-10913713-B2 | Methods of preparing cytotoxic benzodiazepine derivatives | IMMUNOGEN, INC. (US) | 2021-02-09 | — | — | US | disclosed |
| US-10844078-B2 | Methods of preparing cytotoxic benzodiazepine derivatives | IMMUNOGEN, INC. (US) | 2020-11-24 | — | — | US | disclosed |
| US-20200172481-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. | 2020-06-04 | — | — | US | disclosed |
| WO-2020102053-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. (US) | 2020-05-22 | — | — | WO | disclosed |
| US-10385071-B2 | Methods of preparing cytotoxic benzodiazepine derivatives | IMMUNOGEN, INC. (US) | 2019-08-20 | — | — | US | disclosed |
| WO-2018140435-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. (US) | 2018-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230114-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | GABRA3, GABRA5, GABRA6 | PTGS1 2639/4885PTGS2 2377/4885OPRM1 160/4885 |
| US-10913713-B2 | Methods of preparing cytotoxic benzodiazepine derivatives | GABRA3, GABRA5, GABRA6 | PTGS1 2639/4885PTGS2 2377/4885OPRM1 160/4885 |
| US-10844078-B2 | Methods of preparing cytotoxic benzodiazepine derivatives | GABRA3, GABRA5, GABRA6 | PTGS1 2639/4885PTGS2 2377/4885OPRM1 160/4885 |
| US-10385071-B2 | Methods of preparing cytotoxic benzodiazepine derivatives | GABRA3, GABRA5, GABRA6 | PTGS1 2639/4885PTGS2 2377/4885OPRM1 160/4885 |
| US-20230039161-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | GABRA3, GABRA5, GABRA6 | PTGS1 2639/4885PTGS2 2377/4885OPRM1 160/4885 |
| US-20210139510-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | GABRA3, GABRA5, GABRA6 | PTGS1 2639/4885PTGS2 2377/4885OPRM1 160/4885 |
| US-20200172481-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | GABRA3, GABRA5, GABRA6 | PTGS1 2639/4885PTGS2 2377/4885OPRM1 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.