Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29819860 | 0.83 | KMT2A (0.60) | KMT2AMEN1POLBMAPTHPGD | |
| SCHEMBL10922984 | 0.83 | KMT2A (0.60) | KMT2AMEN1POLBMAPTHPGD | |
| SCHEMBL12431374 | 0.81 | NPSR1 (0.53) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL17114059 | 0.79 | KMT2A (0.42) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL7224723 | 0.79 | MGLL (0.60) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL3065646 | 0.77 | ELANE (0.61) | KMT2AMEN1ALDH1A1HPGDNPSR1 | |
| SCHEMBL20804319 | 0.77 | ALDH1A1 (0.58) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL10341837 | 0.77 | KMT2A (0.65) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL14302318 | 0.76 | TERT (0.50) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL19380789 | 0.75 | KMT2A (0.64) | KMT2AMEN1POLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119768-B1 | 3,4-BROMO OR -SULFONATE SUBSTITUTED 1H-PYRROLE-2,5-DIONE DERIVATIVES AS TYPE III DEIODINASE (DIO3) INHIBITORS FOR TREATING DEPRESSIONS AND CANCER | HADASIT MED RES SERVICE (IL) | 2019-07-31 | — | — | EP | disclosed |
| US-20180215709-A1 | TYPE III DEIODINASE INHIBITORS AND USES THEREOF | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215709-A1 | TYPE III DEIODINASE INHIBITORS AND USES THEREOF | TPO, DPP3, HSD17B3 | KMT2A 1358/4885MEN1 1356/4885POLB 1775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.