Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | TNKS | O95271 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.44 |
| ▸ | GABRD | O14764 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18397848 | 0.81 | GABRP (0.46) | ABCG2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL18397890 | 0.81 | ABCG2 (0.41) | PPARGCYP11B1CYP11B2ABCG2TNKS | |
| SCHEMBL18397898 | 0.78 | PPARG (0.57) | PPARGCYP11B1ABCG2ABCB1NPC1 | |
| SCHEMBL18397910 | 0.78 | PPARG (0.57) | PPARGCYP11B1CYP11B2ABCG2TNKS | |
| SCHEMBL18397797 | 0.77 | LOXL2 (0.60) | PPARGABCG2CYP1B1CYP3A4HPGD | |
| SCHEMBL18397892 | 0.74 | MMP12 (0.38) | PPARGCYP11B1CYP11B2ABCG2KDM4E | |
| SCHEMBL18397855 | 0.74 | ABCG2 (0.37) | CYP11B1CYP11B2ABCG2KDM4EALDH1A1 | |
| SCHEMBL3395103 | 0.74 | PPARG (0.63) | PPARGCYP11B1CYP11B2ABCG2SIGMAR1 | |
| SCHEMBL5695477 | 0.74 | PPARG (0.63) | PPARGCYP11B1CYP11B2ABCG2SIGMAR1 | |
| SCHEMBL9471231 | 0.74 | PPARG (0.63) | PPARGCYP11B1CYP11B2ABCG2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180215727-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. | 2018-08-02 | — | — | US | disclosed |
| US-20180215727-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215727-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | LOXL2, LOXL1, LOX | PPARG 2000/4885CYP11B1 1314/4885CYP11B2 686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.