Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20425657 | 0.90 | SMN1; SMN2 (0.37) | SMN1; SMN2TSHRHCRTR1HCRTR2MAPT | |
| SCHEMBL20425562 | 0.90 | SMN1; SMN2 (0.37) | SMN1; SMN2TSHRHCRTR1HCRTR2MAPT | |
| SCHEMBL20439674 | 0.90 | SMN1; SMN2 (0.37) | SMN1; SMN2TSHRHCRTR1HCRTR2MAPT | |
| SCHEMBL20440047 | 0.82 | TP53 (0.44) | TSHRHCRTR2MAPTHPGDOPRM1 | |
| SCHEMBL20425598 | 0.79 | MGLL (0.40) | OPRM1OPRD1OPRK1MGLL | |
| SCHEMBL20425710 | 0.79 | MGLL (0.40) | OPRM1OPRD1OPRK1MGLL | |
| SCHEMBL20440028 | 0.79 | MGLL (0.40) | OPRM1OPRD1OPRK1MGLL | |
| SCHEMBL20439781 | 0.77 | MAOA (0.38) | HCRTR2MAPTHPGDOPRM1OPRD1 | |
| SCHEMBL20439677 | 0.68 | HTT (0.54) | SMN1; SMN2NPC1HPGDKMT2APOLB | |
| SCHEMBL20425617 | 0.66 | FAAH (0.39) | HCRTR2OPRM1OPRD1OPRK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018140876-A1 | NRF2 ACTIVATOR | BIOGEN MA INC. (US) | 2018-08-02 | — | — | WO | disclosed |