Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 4/20 | 0.34 |
| ▸ | F2 | P00734 | 3/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26673197 | 0.86 | SLC6A3 (0.43) | CES2CES1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL16150533 | 0.85 | CHRNA1 (0.47) | CES2CES1ALDH1A1TSHRF10 | |
| SCHEMBL20455676 | 0.79 | ALDH1A1 (0.43) | ALDH1A1TSHRCYP3A4ALOX15KDM4E | |
| SCHEMBL10510642 | 0.76 | CES2 (0.46) | CES2CES1ALDH1A1TSHRALOX15 | |
| SCHEMBL11732434 | 0.76 | KMT2A (0.53) | ALDH1A1TSHRF10F2MEN1 | |
| SCHEMBL1376478 | 0.75 | CA12 (0.54) | ALDH1A1TSHRTDP1KMT2ACA12 | |
| SCHEMBL6204940 | 0.75 | NPC1 (0.47) | CES2CES1ALDH1A1TSHRNLRP3 | |
| SCHEMBL9806430 | 0.74 | LMNA (0.56) | ALDH1A1TSHRCYP3A4F10F2 | |
| SCHEMBL11730496 | 0.74 | SMN1; SMN2 (0.48) | ALDH1A1TSHRCYP3A4TDP1MEN1 | |
| SCHEMBL29654058 | 0.74 | NPC1 (0.57) | ALDH1A1TSHRALOX15MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110831599-B | Compounds, compositions and methods for cancer treatment | 布罗德研究所股份有限公司 | 2023-03-28 | — | — | CN | disclosed |
| US-11142522-B2 | Compounds, compositions and methods for cancer treatment | THE BROAD INSTITUTE, INC. (US) | 2021-10-12 | — | — | US | disclosed |
| US-11142522-B2 | Compounds, compositions and methods for cancer treatment | THE BROAD INSTITUTE, INC. (US) | 2021-10-12 | — | — | US | disclosed |
| US-20200062741-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER TREATMENT | THE BROAD INSTITUTE, INC. (US) | 2020-02-27 | — | — | US | disclosed |
| US-20200062741-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER TREATMENT | THE BROAD INSTITUTE, INC. (US) | 2020-02-27 | — | — | US | disclosed |
| CN-110831599-A | Compounds, compositions and methods for cancer treatment | 布罗德研究所股份有限公司 | 2020-02-21 | — | — | CN | disclosed |
| WO-2018141835-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER TREATMENT | THE BROAD INSTITUTE, INC. (US) | 2018-08-09 | — | — | WO | disclosed |
| WO-2018141835-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER TREATMENT | THE BROAD INSTITUTE, INC. (US) | 2018-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062741-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER TREATMENT | CREB1, PDE2A, PDE4A | CES2 828/4885CES1 1959/4885ALDH1A1 1509/4885 |
| US-11142522-B2 | Compounds, compositions and methods for cancer treatment | CREB1, PDE2A, PDE4A | CES2 828/4885CES1 1959/4885ALDH1A1 1509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.