Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 7/20 | 0.36 |
| ▸ | DRD4 | P21917 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17665055 | 0.82 | ALDH1A1 (0.52) | GAAALOX12SMN1; SMN2ALDH1A1SLC18A3 | |
| SCHEMBL17642603 | 0.81 | KCNH2 (0.40) | GAAALOX12SMN1; SMN2ALKALDH1A1 | |
| SCHEMBL17642589 | 0.80 | SMN1; SMN2 (0.45) | GAAALOX12SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL17642596 | 0.78 | SMN1; SMN2 (0.39) | GAAALOX12SMN1; SMN2ALKALDH1A1 | |
| SCHEMBL15337444 | 0.78 | TBK1 (0.46) | ALKKITKDR | |
| SCHEMBL17642726 | 0.78 | GAA (0.40) | GAAALOX12SMN1; SMN2ALKINSR | |
| SCHEMBL16440187 | 0.78 | ALDH1A1 (0.43) | GAAALOX12SMN1; SMN2ALDH1A1DRD2 | |
| SCHEMBL12072936 | 0.77 | HTR1A (0.51) | SMN1; SMN2ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL19203563 | 0.77 | ALDH1A1 (0.46) | GAAALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL17665058 | 0.77 | PDE3B (0.40) | GAAALOX12SMN1; SMN2ALDH1A1SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10040781-B2 | Tank-binding kinase inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2018-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10040781-B2 | Tank-binding kinase inhibitor compounds | TBKBP1, TNKS1BP1, TNKS | GAA 3183/4885ALOX12 4388/4885SMN1; SMN2 2291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.