Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9892924 | 0.82 | MEN1 (0.48) | LMNATHRBPOLBGPR119MAPT | |
| SCHEMBL13257808 | 0.78 | MEN1 (0.52) | LMNATHRBPOLBKDM4E | |
| SCHEMBL9892268 | 0.74 | POLB (0.51) | LMNATHRBPOLBMAPT | |
| SCHEMBL20458149 | 0.74 | ALDH1A1 (0.46) | MAPTGAA | |
| SCHEMBL9108039 | 0.73 | HTRA1 (0.40) | LMNATHRBPOLBMAPT | |
| SCHEMBL20458171 | 0.71 | L3MBTL1 (0.48) | POLBGPR119MAPTGAA | |
| SCHEMBL25337486 | 0.69 | GPR119 (0.46) | LMNAGPR119MAPTNR1H3NR1H2 | |
| SCHEMBL20595761 | 0.69 | GPR119 (0.46) | LMNAGPR119MAPTNR1H3NR1H2 | |
| SCHEMBL20458202 | 0.67 | ATAD2 (0.47) | LMNAPOLBMAPTTDP1KDM4E | |
| SCHEMBL20458254 | 0.67 | GRM5 (0.36) | LMNAGPR119MAPTNR1H3NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443107-B1 | AZETIDINE 2 -CARBOXAMIDE DERIVATIVES WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INT (DE) | 2018-08-08 | — | — | EP | disclosed |