SCHEMBL20458583

SCHEMBL20458583

C=C/C=C\c1ccc(NC(C)=O)c(-c2c(N)ccc3ccccc23)c1C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.36
KDM4E B2RXH2 3/20 0.36
HPGD P15428 3/20 0.36
MAPT P10636 2/20 0.36
GLA P06280 1/20 0.35
GAA P10253 1/20 0.35
MTNR1A P48039 1/20 0.34
MTNR1B P49286 1/20 0.34
HDAC3 O15379 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC2 Q92769 1/20 0.34
RXFP1 Q9HBX9 1/20 0.34
PARP14 Q460N5 1/20 0.33
ABCC9 O60706 1/20 0.32
ABCC8 Q09428 1/20 0.32
KCNJ11 Q14654 1/20 0.32
KCNJ8 Q15842 1/20 0.32
POLB P06746 1/20 0.32
DHODH Q02127 2/20 0.32
CHAT P28329 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4125050 0.80 KDM4E (0.49) ALDH1A1KDM4EHPGDMAPTGLA
SCHEMBL20436327 0.72 ALDH1A1 (0.57) ALDH1A1KDM4EHPGDMAPTGLA
SCHEMBL17067963 0.71 CYP2A6 (0.47) ALDH1A1KDM4EHPGDMAPTRAB9A
SCHEMBL18619655 0.68 ABCC9 (0.48) ALDH1A1KDM4EHPGDMAPTGAA
SCHEMBL10609908 0.66 KDM4E (0.54) ALDH1A1KDM4EHPGDMAPTGLA
SCHEMBL7715325 0.66 MAPT (0.51) ALDH1A1KDM4EHPGDMAPTGLA
SCHEMBL30237970 0.66 MEN1 (0.60) MAPTHDAC3HDAC1HDAC2KCNJ11
SCHEMBL20625930 0.65 HDAC1 (0.45) ALDH1A1KDM4EHPGDMAPTGLA
SCHEMBL18685754 0.65 HNF4A (0.42) ALDH1A1KDM4EHPGDMAPTGAA
SCHEMBL17559536 0.65 MEN1 (0.43) ALDH1A1KDM4EHPGDMAPTGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3358346-A1 ENANTIOMER ANALYSIS METHOD Ajinomoto Co., Inc. (JP) 2018-08-08 EP disclosed