Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | XIAP | P98170 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20459280 | 0.78 | XIAP (0.59) | LMNAXIAP | |
| SCHEMBL5250841 | 0.72 | ALDH1A1 (0.53) | LMNAPOLBALDH1A1KMT2AFKBP1A | |
| SCHEMBL21401325 | 0.71 | FKBP1A (0.59) | POLBALDH1A1HPGDUSP2NPSR1 | |
| SCHEMBL6380737 | 0.71 | FKBP1A (0.59) | POLBALDH1A1HPGDUSP2NPSR1 | |
| SCHEMBL21696512 | 0.70 | HPGD (0.47) | ALDH1A1HPGDUSP2MC4RNPSR1 | |
| SCHEMBL928146 | 0.69 | LMNA (0.52) | LMNAXIAPALDH1A1 | |
| SCHEMBL4235379 | 0.68 | P2RX4 (0.66) | LMNAALDH1A1MEN1GAAKMT2A | |
| SCHEMBL5218354 | 0.68 | NOTUM (0.41) | ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL14299315 | 0.67 | P2RX7 (0.70) | ALDH1A1 | |
| SCHEMBL17268009 | 0.67 | ALDH1A1 (0.59) | ALDH1A1HPGDUSP2KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906535-B1 | INDOLINES | HOFFMANN LA ROCHE (CH) | 2018-08-08 | — | — | EP | disclosed |