Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14931681 | 1.00 | ALDH1A1 (0.52) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL1487621 | 0.84 | ALDH1A1 (0.71) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL2044950 | 0.83 | KDM4E (0.40) | ALDH1A1KDM4ELMNAMAPTMEN1 | |
| SCHEMBL8502354 | 0.82 | CYP2A6 (0.50) | ALDH1A1KDM4ELMNAHPGDMAPT | |
| SCHEMBL11299778 | 0.81 | ALDH1A1 (0.57) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL4059355 | 0.80 | ALDH1A1 (0.61) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL30178662 | 0.80 | ALDH1A1 (0.63) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL29890082 | 0.80 | ERN1 (0.58) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL153974 | 0.80 | ERN1 (0.58) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL11173 | 0.80 | ALDH1A1 (0.63) | ALDH1A1KDM4ETSHRTDP1PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2573067-B1 | AROMATIC BUTAN-2-OL COMPOUNDS, PREPARATION METHODS AND USES THEREOF | INST PHARMACOLOGY & TOXICOLOGY ACADEMY MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2018-10-10 | — | — | EP | disclosed |
| US-8674136-B2 | Aromatic butan-2-ol compounds and preparation and uses thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2014-03-18 | — | — | US | disclosed |
| US-8674136-B2 | Aromatic butan-2-ol compounds and preparation and uses thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2014-03-18 | — | — | US | disclosed |
| US-8674136-B2 | Aromatic butan-2-ol compounds and preparation and uses thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2014-03-18 | — | — | US | disclosed |
| EP-2364321-B1 | HCV inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2013-04-17 | — | — | EP | disclosed |
| EP-2364321-B1 | HCV inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2013-04-17 | — | — | EP | disclosed |
| US-20130085183-A1 | AROMATIC BUTAN-2-OL COMPOUNDS AND PREPARATION AND USES THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2013-04-04 | — | — | US | disclosed |
| US-20130085183-A1 | AROMATIC BUTAN-2-OL COMPOUNDS AND PREPARATION AND USES THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2013-04-04 | — | — | US | disclosed |
| EP-2573067-A1 | AROMATIC BUTAN-2-OL COMPOUNDS, PREPARATION METHODS AND USES THEREOF | Institute Of Pharmacology And Toxicology Academy Of Militaty Medical Sciences P.L.A. (CN) | 2013-03-27 | — | — | EP | disclosed |
| EP-2573067-A1 | AROMATIC BUTAN-2-OL COMPOUNDS, PREPARATION METHODS AND USES THEREOF | Institute Of Pharmacology And Toxicology Academy Of Militaty Medical Sciences P.L.A. (CN) | 2013-03-27 | — | — | EP | disclosed |
| US-20100272674-A1 | Hepatitis C Virus Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2010-10-28 | — | — | US | disclosed |
| US-20100272674-A1 | Hepatitis C Virus Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2010-10-28 | — | — | US | disclosed |
| US-20100272674-A1 | Hepatitis C Virus Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2010-10-28 | — | — | US | disclosed |
| WO-2010065577-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-06-10 | — | — | WO | disclosed |
| WO-2010065577-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-06-10 | — | — | WO | disclosed |
| WO-2010036551-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010036551-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-01 | — | — | WO | disclosed |
| US-20100080770-A1 | Hepatitis C Virus Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2010-04-01 | — | — | US | disclosed |
| US-20100080770-A1 | Hepatitis C Virus Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2010-04-01 | — | — | US | disclosed |
| US-20100080770-A1 | Hepatitis C Virus Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2010-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100080770-A1 | Hepatitis C Virus Inhibitors | HAVCR2, HCCS, PYGL | ALDH1A1 623/4885KDM4E 3825/4885TSHR 4631/4885 |
| US-20100272674-A1 | Hepatitis C Virus Inhibitors | HAVCR2, HCCS, GOT1 | ALDH1A1 421/4885KDM4E 4022/4885TSHR 4649/4885 |
| US-20130085183-A1 | AROMATIC BUTAN-2-OL COMPOUNDS AND PREPARATION AND USES THEREOF | TMBIM6, SORD, TBC1D5 | ALDH1A1 872/4885KDM4E 3183/4885TSHR 3747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.