Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | EEF2K | O00418 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2039507 | 0.87 | ALDH1A1 (0.35) | ALDH1A1POLBOPRL1KDM4ENPC1 | |
| SCHEMBL2039497 | 0.80 | ALOX15 (0.34) | ALDH1A1TSHRRBBP9CYP3A4CYP2D6 | |
| SCHEMBL2053963 | 0.76 | LMNA (0.36) | ALDH1A1OPRL1SLC6A4SLC6A3KDM4E | |
| SCHEMBL2016931 | 0.75 | LMNA (0.38) | ALDH1A1POLBOPRL1SLC6A4SLC6A3 | |
| SCHEMBL3797646 | 0.73 | ALDH1A1 (0.35) | ALDH1A1POLBOPRL1KDM4EL3MBTL1 | |
| SCHEMBL2040851 | 0.73 | LMNA (0.39) | ALDH1A1OPRL1NPC1RAB9AL3MBTL1 | |
| SCHEMBL2037379 | 0.68 | PDE4A (0.34) | ALDH1A1POLBOPRL1L3MBTL1EEF2K | |
| SCHEMBL2035833 | 0.67 | AKR1C1 (0.42) | ALDH1A1POLBOPRL1SLC6A4SLC6A3 | |
| SCHEMBL2037649 | 0.67 | AKR1C1 (0.42) | ALDH1A1POLBOPRL1SLC6A4SLC6A3 | |
| SCHEMBL2834514 | 0.67 | OPRL1 (0.36) | ALDH1A1OPRL1TSHRDPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |