Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TXNRD1 | Q16881 | 3/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19236925 | 0.98 | PDE10A (0.45) | PDE10AALOX5PTGS2TDP1POLB | |
| SCHEMBL20467095 | 0.81 | ALOX5 (0.41) | ALOX5PTGS2TDP1KCNH2MEN1 | |
| SCHEMBL21230758 | 0.80 | ALOX5 (0.40) | ALOX5PTGS2TDP1KCNH2MEN1 | |
| SCHEMBL9908276 | 0.80 | POLB (0.52) | PDE10ATDP1POLBTXNRD1MEN1 | |
| SCHEMBL24306090 | 0.75 | SMPD1 (0.43) | TDP1POLBTXNRD1GSR | |
| SCHEMBL1848182 | 0.74 | POLB (0.46) | PDE10ATDP1POLBMEN1MAPT | |
| SCHEMBL18291529 | 0.74 | POLB (0.46) | PDE10ATDP1POLBMEN1TSHR | |
| SCHEMBL6408365 | 0.74 | POLB (0.50) | PTGS2TDP1POLBMEN1MAPT | |
| SCHEMBL675903 | 0.72 | ALOX5 (0.49) | ALOX5PTGS2TDP1KCNH2PPARA | |
| SCHEMBL26612262 | 0.72 | PDE10A (0.44) | PDE10AALOX5PTGS2TXNRD1GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10308975-B2 | Substituted imidazo[1,2-a]pyrazines as luciferase substrates | PROMEGA CORPORATION (US) | 2019-06-04 | — | — | US | disclosed |
| US-20180223330-A1 | COELENTERAZINE ANALOGUES | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2018-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180223330-A1 | COELENTERAZINE ANALOGUES | GLB1, SI, TCF7L2 | PDE10A 341/4885ALOX5 3906/4885PTGS2 2136/4885 |
| US-10308975-B2 | Substituted imidazo[1,2-a]pyrazines as luciferase substrates | AADAC, PGLS, GLB1 | PDE10A 317/4885ALOX5 2791/4885PTGS2 632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.