SCHEMBL20468290

SCHEMBL20468290

CCSc1ccc(Br)nc1-c1nc2cc(C(F)(F)F)nc(C#N)c2n1C

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ PSMD14 O00487 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ L3MBTL1 Q9Y468 1/20 0.32
▸ EIF4EBP1 Q13541 1/20 0.31
▸ PKM P14618 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29521322 1.00 ALDH1A1 (0.32) ALDH1A1MEN1PSMD14LMNAKMT2A
SCHEMBL20465926 0.89 ALDH1A1 (0.32) ALDH1A1MEN1PSMD14LMNAKMT2A
SCHEMBL29521552 0.89 L3MBTL1 (0.36) ALDH1A1MEN1PSMD14LMNAKMT2A
SCHEMBL20455822 0.89 L3MBTL1 (0.36) ALDH1A1MEN1PSMD14LMNAKMT2A
SCHEMBL29521456 0.87 ALDH1A1 (0.33) ALDH1A1L3MBTL1PKM
SCHEMBL20468387 0.87 ALDH1A1 (0.33) ALDH1A1L3MBTL1PKM
SCHEMBL29521430 0.85 ALDH1A1 (0.32) ALDH1A1
SCHEMBL20468388 0.85 ALDH1A1 (0.32) ALDH1A1
SCHEMBL29521336 0.85 L3MBTL1 (0.33) ALDH1A1MEN1LMNAKMT2AL3MBTL1
SCHEMBL20455823 0.85 L3MBTL1 (0.33) ALDH1A1MEN1LMNAKMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110248942-B Process for preparing halogenated imidazopyridine derivatives 拜耳公司 2022-04-19 — — CN disclosed
EP-3577114-B1 METHOD FOR THE PREPARATION OF HALOGENATED IMIDAZOPYRIDINE DERIVATIVES BAYER AG (DE) 2021-11-10 — — EP disclosed
US-11072609-B2 Method for preparing halogenated imidazopyridine derivatives BAYER AKTIENGESELLSCHAFT (DE) 2021-07-27 — — US disclosed
US-11072609-B2 Method for preparing halogenated imidazopyridine derivatives BAYER AKTIENGESELLSCHAFT (DE) 2021-07-27 — — US disclosed
US-20210094947-A1 METHOD FOR PREPARING HALOGENATED IMIDAZOPYRIDINE DERIVATIVES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2021-04-01 — — US disclosed
US-20210094947-A1 METHOD FOR PREPARING HALOGENATED IMIDAZOPYRIDINE DERIVATIVES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2021-04-01 — — US disclosed
WO-2018141955-A1 PROCESS FOR PREPARING HALOGENATED IMIDAZOPYRIDINE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2018-08-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210094947-A1 METHOD FOR PREPARING HALOGENATED IMIDAZOPYRIDINE DERIVATIVES CYP2F1, CYP2D6, POLR2A ALDH1A1 853/4885MEN1 1024/4885PSMD14 3841/4885
US-11072609-B2 Method for preparing halogenated imidazopyridine derivatives CYP2F1, CYP2D6, POLR2A ALDH1A1 853/4885MEN1 1024/4885PSMD14 3841/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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