Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 19/20 | 0.54 |
| ▸ | TNF | P01375 | 4/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29709747 | 0.84 | IRAK4 (0.48) | IRAK4 | |
| SCHEMBL24508596 | 0.84 | IRAK4 (0.48) | IRAK4 | |
| SCHEMBL29709894 | 0.84 | IRAK4 (0.48) | IRAK4 | |
| SCHEMBL26598605 | 0.77 | IRAK4 (0.61) | IRAK4 | |
| SCHEMBL31436622 | 0.77 | IRAK4 (0.61) | IRAK4 | |
| SCHEMBL15742080 | 0.75 | EGFR (0.55) | IRAK4TNFCNR2 | |
| SCHEMBL21765615 | 0.75 | IRAK4 (0.57) | IRAK4 | |
| SCHEMBL21765613 | 0.74 | IRAK4 (0.53) | IRAK4TNF | |
| SCHEMBL18341524 | 0.74 | KDM4E (0.43) | IRAK4TNF | |
| SCHEMBL30545204 | 0.74 | KDM4E (0.43) | IRAK4TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3583105-B1 | PYRROLO [1,2-B]PYRIDAZINE DERIVATIVES | GILEAD SCIENCES INC (US) | 2024-02-07 | — | — | EP | disclosed |
| US-10336762-B2 | Pyrrolo[1,2-b]pyridazine derivatives | GILEAD SCIENCES, INC. (US) | 2019-07-02 | — | — | US | disclosed |
| WO-2018152368-A1 | PYRROLO [1,2-B] PYRIDAZINE DERIVATIVES | GILEAD SCIENCES, INC. (US) | 2018-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336762-B2 | Pyrrolo[1,2-b]pyridazine derivatives | SDHB, CYP4F2, CYP1B1 | IRAK4 2924/4885TNF 3417/4885CNR2 746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.