Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20482125 | 1.00 | KDM2B (0.52) | KDM2BPKMNPSR1MEN1KMT2A | |
| SCHEMBL20524450 | 0.87 | POLB (0.51) | KDM2BKMT2ACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL4776118 | 0.84 | KDM2B (0.51) | KDM2BMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL20482105 | 0.82 | NPC1 (0.52) | KDM2BNPSR1MEN1KMT2AALDH1A1 | |
| SCHEMBL20482718 | 0.79 | THRB (0.43) | KMT2AALDH1A1 | |
| SCHEMBL20482159 | 0.79 | THRB (0.43) | KMT2AALDH1A1 | |
| SCHEMBL20482089 | 0.78 | CES2 (0.39) | KMT2AALDH1A1 | |
| SCHEMBL20482428 | 0.76 | ALDH1A1 (0.49) | ALDH1A1 | |
| SCHEMBL20482097 | 0.76 | ALDH1A1 (0.49) | ALDH1A1 | |
| SCHEMBL3001673 | 0.76 | ALDH1A1 (0.49) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018153820-A1 | PROCESS FOR THE PREPARATION OF CHIRAL PYROLLIDINE-2-YL- METHANOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-08-30 | — | — | WO | disclosed |