SCHEMBL2048445

SCHEMBL2048445

CC(C)(C)C(P)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 1/20 0.44
CYP17A1 P05093 3/20 0.44
CHRNB2 P17787 1/20 0.42
CHRNA4 P43681 1/20 0.42
ACP3 P15309 2/20 0.39
ALDH1A1 P00352 1/20 0.39
TAAR1 Q96RJ0 1/20 0.38
KIF11 P52732 1/20 0.37
FASN P49327 1/20 0.37
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27987298 0.84 SLC6A4 (0.47) ALDH1A1TAAR1SLC6A2SLC6A4SLC6A3
SCHEMBL27760398 0.82 RXRA (0.41) CHRNB2CHRNA4ALDH1A1KIF11SLC6A2
SCHEMBL27968853 0.76 ALOX5 (0.35) CYP17A1ALDH1A1TAAR1KIF11FASN
SCHEMBL26826452 0.76 PTGS2 (0.50) PTGS2CYP17A1CHRNB2CHRNA4ACP3
SCHEMBL6721043 0.72 PTGS2 (0.43) PTGS2CYP17A1CHRNB2CHRNA4TAAR1
Biphenyl SCHEMBL27775455 0.70 ALDH1A1 (0.60) ALDH1A1TAAR1KIF11CYP3A4SLC6A4
Biphenyl SCHEMBL3105248 0.70 ALDH1A1 (0.60) PTGS2ALDH1A1TAAR1CYP3A4SLC6A4
Biphenyl SCHEMBL9503944 0.70 ALDH1A1 (0.60) PTGS2ALDH1A1TAAR1CYP3A4SLC6A4
SCHEMBL17892366 0.70 PTGS2 (0.54) PTGS2CYP17A1CHRNB2CHRNA4ACP3
Biphenyl SCHEMBL27745920 0.69 ALDH1A1 (0.69) ALDH1A1TAAR1KIF11CYP3A4SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073653-A1 IMPROVED CARBONYLATION PROCESS LUCITE INTERNATIONAL UK LIMITED (GB) 2011-06-23 WO disclosed
WO-2011073655-A1 A CONTINUOUS PROCESS FOR THE CARBONYLATION OF ETHYLENE LUCITE INTERNATIONAL UK LIMITED (GB) 2011-06-23 WO disclosed