Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 8/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20488362 | 0.83 | USP2 (0.40) | — | |
| SCHEMBL20487513 | 0.78 | RORA (0.35) | DRD2SIGMAR1 | |
| SCHEMBL1807709 | 0.77 | OPRL1 (0.53) | OPRL1SIGMAR1 | |
| SCHEMBL21681635 | 0.76 | OPRL1 (0.38) | OPRL1 | |
| SCHEMBL18579749 | 0.76 | OPRL1 (0.38) | OPRL1 | |
| SCHEMBL20487426 | 0.75 | TAAR1 (0.35) | SIGMAR1 | |
| SCHEMBL23223306 | 0.72 | USP2 (0.40) | — | |
| SCHEMBL13560088 | 0.69 | L3MBTL1 (0.38) | OPRL1DRD2OPRM1 | |
| SCHEMBL21681621 | 0.68 | HHAT (0.36) | OPRL1 | |
| SCHEMBL21681614 | 0.68 | HHAT (0.36) | OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3589637-B1 | COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T | LILLY CO ELI (US) | 2021-04-14 | — | — | EP | disclosed |
| US-10603320-B2 | Compounds useful for inhibiting ROR-gamma-t | ELI LILLY AND COMPANY (US) | 2020-03-31 | — | — | US | disclosed |
| WO-2018160547-A1 | COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T | ELI LILLY AND COMPANY (US) | 2018-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10603320-B2 | Compounds useful for inhibiting ROR-gamma-t | RORC, RORB, RORA | OPRL1 2163/4885DRD2 4135/4885SIGMAR1 2260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.