Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23223306 | 0.89 | USP2 (0.40) | USP2SMN1; SMN2SCD5AVPR1ATSHR | |
| SCHEMBL20487669 | 0.83 | OPRL1 (0.39) | — | |
| SCHEMBL1807425 | 0.82 | OPRL1 (0.47) | USP2SMN1; SMN2AVPR1AGPR119NR1H2 | |
| SCHEMBL20486729 | 0.81 | GPR119 (0.37) | USP2SMN1; SMN2SCD5ALDH1A1LMNA | |
| SCHEMBL21710554 | 0.80 | USP2 (0.40) | USP2SMN1; SMN2SCD5AVPR1AGPR119 | |
| SCHEMBL18590703 | 0.80 | USP2 (0.40) | USP2SMN1; SMN2SCD5AVPR1AGPR119 | |
| SCHEMBL18579748 | 0.80 | USP2 (0.40) | USP2SMN1; SMN2SCD5AVPR1AGPR119 | |
| SCHEMBL25357154 | 0.76 | USP2 (0.41) | USP2SMN1; SMN2SCD5ALDH1A1LMNA | |
| SCHEMBL25356737 | 0.74 | USP2 (0.41) | USP2SMN1; SMN2SCD5AVPR1ATSHR | |
| SCHEMBL25360337 | 0.74 | SIGMAR1 (0.48) | USP2SMN1; SMN2SCD5AVPR1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110392688-B | Compounds for inhibition of ROR-gamma-T | 伊莱利利公司 | 2021-09-10 | — | — | CN | disclosed |
| EP-3589637-B1 | COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T | LILLY CO ELI (US) | 2021-04-14 | — | — | EP | disclosed |
| EP-3589637-B1 | COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T | LILLY CO ELI (US) | 2021-04-14 | — | — | EP | disclosed |
| US-10603320-B2 | Compounds useful for inhibiting ROR-gamma-t | ELI LILLY AND COMPANY (US) | 2020-03-31 | — | — | US | disclosed |
| WO-2018160547-A1 | COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T | ELI LILLY AND COMPANY (US) | 2018-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10603320-B2 | Compounds useful for inhibiting ROR-gamma-t | RORC, RORB, RORA | USP2 3559/4885SMN1; SMN2 4643/4885SCD5 2062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.