Fludrocortisone

Fludrocortisone

SCHEMBL13026141

CC12CCC(=O)C=C1CCC1C3CCC(O)(C(=O)CO)C3(C)CC(O)C12F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 P04150 7/20 1.00
▸ PGR P06401 4/20 0.78
▸ HIF1A Q16665 4/20 0.78
▸ HRH1 P35367 1/20 0.78
▸ SERPINA6 P08185 3/20 0.76
▸ HSD17B10 Q99714 4/20 0.73
▸ AR P10275 3/20 0.73
▸ ALDH1A1 P00352 1/20 0.68
▸ MAPK1 P28482 1/20 0.68
▸ FNTA P49354 1/20 0.68
▸ FNTB P49356 1/20 0.68
▸ LMNA P02545 2/20 0.64
▸ CYP2C19 P33261 3/20 0.61
▸ CYP3A4 P08684 4/20 0.58
▸ SHBG P04278 2/20 0.58
▸ SMN1; SMN2 Q16637 2/20 0.58
▸ NR3C2 P08235 1/20 0.58
▸ MAPT P10636 1/20 0.58
▸ NFKB1 P19838 1/20 0.58
▸ KMT2A Q03164 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fludrocortisone SCHEMBL5188889 1.00 NR3C1 (1.00) NR3C1PGRHIF1AHRH1SERPINA6
Fludrocortisone SCHEMBL4545 1.00 NR3C1 (1.00) NR3C1PGRHIF1AHRH1SERPINA6
Fludrocortisone SCHEMBL19327146 1.00 NR3C1 (1.00) NR3C1PGRHIF1AHRH1SERPINA6
Fludrocortisone SCHEMBL4323075 1.00 NR3C1 (1.00) NR3C1PGRHIF1AHRH1SERPINA6
Fludrocortisone SCHEMBL10598529 1.00 NR3C1 (1.00) NR3C1PGRHIF1AHRH1SERPINA6
Fludrocortisone SCHEMBL23975175 1.00 NR3C1 (1.00) NR3C1PGRHIF1AHRH1SERPINA6
Fludrocortisone SCHEMBL14373312 1.00 NR3C1 (1.00) NR3C1PGRHIF1AHRH1SERPINA6
Fludrocortisone SCHEMBL21297043 0.98 NR3C1 (0.96) NR3C1PGRHIF1AHRH1SERPINA6
SCHEMBL8735123 0.93 NR3C1 (0.87) NR3C1PGRHIF1AHRH1SERPINA6
SCHEMBL8735124 0.93 NR3C1 (0.87) NR3C1PGRHIF1AHRH1SERPINA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4079311-B1 NMN AND DERIVATIVES FOR USE IN THE TREATMENT OF DEPRESSION AND/OR ANXIETY IN PATIENTS HAVING A FORM OF PARKINSONISM NUVAMID SA (CH) 2025-10-01 — — EP claimed
EP-2796112-B2 Degradable implantable medical devices ELIXIR MEDICAL CORP (US) 2023-08-09 — — EP claimed
WO-2018050938-A1 PRE-LOADED INJECTABLE DEVICE FOR TREATING CEREBRAL EDEMA SERVICIO ANDALUZ DE SALUD (ES) 2018-03-22 — — WO claimed
CN-1320880-C Improved formulation for topical non-invasive application in vivo IDEA INNOVAT DERMALE APPL GMBH (DE) 2007-06-13 — — CN claimed
CN-1327382-A Improved formulation for topical non-invasive application in vivo IDEA INNOVAT DERMALE APPL GMBH (DE) 2001-12-19 — — CN claimed
EP-3350313-B1 DERIVATION OF LIVER ORGANOIDS FROM HUMAN PLURIPOTENT STEM CELLS AGENCY FOR SCIENCE TECH AND RESEARCH ASTARSTAR (SG) 2025-11-26 — — EP disclosed
WO-2018050938-A1 PRE-LOADED INJECTABLE DEVICE FOR TREATING CEREBRAL EDEMA SERVICIO ANDALUZ DE SALUD (ES) 2018-03-22 — — WO disclosed
EP-3238781-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF FLUID ACCUMULATION IN AND/ OR UNDER THE RETINA INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2017-11-01 — — EP disclosed
US-9610294-B2 Methods and compositions for the treatment of fluid accumulation in and/or under the retina INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) 2017-04-04 — — US disclosed
US-20170027860-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF OCULAR INFLAMMATORY DISEASES INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) (FR) 2017-02-02 — — US disclosed
EP-2977084-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF FLUID ACCUMULATION IN AND/ OR UNDER THE RETINA INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2016-01-27 — — EP disclosed
EP-2568986-B1 Methods and compositions for the treatment of fluid accumulation in and/ or under the retina INSERM INST NAT DE LA SANTÉ ET DE LA RECH MÉDICALE (FR) 2016-01-13 — — EP disclosed
US-20130131024-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF FLUID ACCUMULATION IN AND/ OR UNDER THE RETINA INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) 2013-05-23 — — US disclosed
US-20100286107-A1 Oligomer-Corticosteroid Conjugates NEKTAR THERAPEUTICS (US) 2010-11-11 — — US disclosed
US-20100286107-A1 Oligomer-Corticosteroid Conjugates NEKTAR THERAPEUTICS (US) 2010-11-11 — — US disclosed
WO-2009045539-A2 OLIGOMER-CORTICOSTEROID CONJUGATES NEKTAR THERAPEUTICS AL, CORPORATION (US) 2009-04-09 — — WO disclosed
CN-1320880-C Improved formulation for topical non-invasive application in vivo IDEA INNOVAT DERMALE APPL GMBH (DE) 2007-06-13 — — CN disclosed
CN-1082363-C Methods of using cyclicpolyanionic polyol derivatives for regulating skin wrinkles P & G CO (US) 2002-04-10 — — CN disclosed
CN-1327382-A Improved formulation for topical non-invasive application in vivo IDEA INNOVAT DERMALE APPL GMBH (DE) 2001-12-19 — — CN disclosed
CN-1145584-A Methods of using cyclicpolyanionic polyol derivatives for regulating skin wrinkles PROCTER & GAMBLE (US) 1997-03-19 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130131024-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF FLUID ACCUMULATION IN AND/ OR UNDER THE RETINA AQP3, AQP1, AQP4 NR3C1 594/4885PGR 1818/4885HIF1A 364/4885
US-20100286107-A1 Oligomer-Corticosteroid Conjugates SERPINA6, NR3C2, NR3C1 NR3C1 3/4885PGR 1161/4885HIF1A 4786/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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