Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27766777 | 0.95 | KIF11 (0.37) | KIF11HSD17B10SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL4770134 | 0.77 | KIF11 (0.36) | KIF11HSD17B10L3MBTL1POLBALDH1A1 | |
| SCHEMBL27858991 | 0.76 | PIK3C3 (0.32) | KIF11HSD17B10ALDH1A1NOS3NOS2 | |
| SCHEMBL29539147 | 0.76 | KIF11 (0.42) | KIF11HSD17B10SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL2043681 | 0.76 | KIF11 (0.31) | KIF11 | |
| SCHEMBL20789355 | 0.75 | ADORA3 (0.31) | ADORA3ADORA2AADORA2BADORA1NOS3 | |
| SCHEMBL20789277 | 0.74 | NOS3 (0.33) | HSD17B10ALDH1A1ADORA3ADORA2AADORA2B | |
| SCHEMBL17376025 | 0.74 | DRD2 (0.39) | — | |
| SCHEMBL498175 | 0.73 | — | — | |
| SCHEMBL17166456 | 0.71 | LRRK2 (0.39) | KIF11LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336315-A2 | Enzymatic encoding methods for efficient synthesis of large libraries | Nuevolution A/S (DK) | 2011-06-22 | — | — | EP | claimed |
| US-11648245-B2 | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators | CORCEPT THERAPEUTICS, INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-11576907-B2 | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators | CORCEPT THERAPEUTICS, INC. (US) | 2023-02-14 | — | — | US | disclosed |
| US-20210369701-A1 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS, INC. | 2021-12-02 | — | — | US | disclosed |
| US-20210169872-A1 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS, INC. | 2021-06-10 | — | — | US | disclosed |
| US-10973813-B2 | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators | CORCEPT THERAPEUTICS, INC. (US) | 2021-04-13 | — | — | US | disclosed |
| US-9956216-B2 | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators | CORCEPT THERAPEUTICS, INC. (US) | 2018-05-01 | — | — | US | disclosed |
| US-20170273972-A1 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS, INC. | 2017-09-28 | — | — | US | disclosed |
| US-9707223-B2 | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators | CORCEPT THERAPEUTICS, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-20170020860-A1 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS, INC. | 2017-01-26 | — | — | US | disclosed |
| US-9273047-B2 | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators | CORCEPT THERAPEUTICS, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-20150080389-A1 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS, INC. | 2015-03-19 | — | — | US | disclosed |
| CN-101848897-A | Gamma secretase modulators | SCHERING CORP | 2010-09-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210169872-A1 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, NR5A1 | KIF11 2788/4885HSD17B10 132/4885SMN1; SMN2 4873/4885 |
| US-11648245-B2 | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators | NR3C1, GRIN3A, NR3C2 | KIF11 1634/4885HSD17B10 301/4885SMN1; SMN2 181/4885 |
| US-20170020860-A1 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, NR5A1 | KIF11 2788/4885HSD17B10 132/4885SMN1; SMN2 4873/4885 |
| US-20210369701-A1 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, GRIN3A, NR3C2 | KIF11 1634/4885HSD17B10 301/4885SMN1; SMN2 181/4885 |
| US-10973813-B2 | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators | NR3C1, NR3C2, NR5A1 | KIF11 2788/4885HSD17B10 132/4885SMN1; SMN2 4873/4885 |
| US-20170273972-A1 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, NR5A1 | KIF11 2788/4885HSD17B10 132/4885SMN1; SMN2 4873/4885 |
| US-11576907-B2 | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators | NR3C1, NR3C2, NR5A1 | KIF11 2788/4885HSD17B10 132/4885SMN1; SMN2 4873/4885 |
| US-20150080389-A1 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, NR5A1 | KIF11 2788/4885HSD17B10 132/4885SMN1; SMN2 4873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.