Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | AOC1 | P19801 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20814491 | 0.86 | LMNA (0.50) | PDE4ALMNAIDH1VCPKMT2A | |
| SCHEMBL8054361 | 0.86 | IDH1 (0.46) | IDH1AOC1AOC3APPPTGS2 | |
| SCHEMBL15720156 | 0.84 | PDE4A (0.41) | PDE4ALMNAIDH1PTGS2VCP | |
| SCHEMBL24167944 | 0.81 | KMT2A (0.40) | PDE4ALMNAKMT2AGSK3BCA2 | |
| SCHEMBL29197980 | 0.81 | KCNH3 (0.54) | LMNAPTGS2VCP | |
| SCHEMBL23431616 | 0.78 | GAA (0.61) | PDE4ALMNAMEN1KMT2A | |
| SCHEMBL8039831 | 0.77 | APP (0.51) | IDH1AOC1AOC3APPPTGS2 | |
| SCHEMBL8053409 | 0.77 | APP (0.51) | IDH1AOC1AOC3APPPTGS2 | |
| SCHEMBL10168927 | 0.75 | KMT2A (0.57) | LMNAIDH1MEN1KMT2A | |
| SCHEMBL26819168 | 0.75 | KCNH3 (0.44) | LMNAPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10814010-B2 | FOXC2 inhibitor and methods of use thereof | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-10-27 | — | — | US | disclosed |
| WO-2020146779-A1 | mTORC1 INHIBITORS FOR ACTIVATING AUTOPHAGY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-07-16 | — | — | WO | disclosed |
| US-20190290774-A1 | FOXC2 INHIBITOR AND METHODS OF USE THEREOF | POHANG UNIVERSITY OF SCIENCE AND TECHNOLOGY (KR) | 2019-09-26 | — | — | US | disclosed |
| WO-2018175958-A1 | THIOREDOXIN MODULATORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190290774-A1 | FOXC2 INHIBITOR AND METHODS OF USE THEREOF | FOXK1, FOXO1, NCOA2 | PDE4A 2741/4885LMNA 3070/4885IDH1 1012/4885 |
| US-10814010-B2 | FOXC2 inhibitor and methods of use thereof | FOXK1, FOXO1, NCOA2 | PDE4A 2741/4885LMNA 3070/4885IDH1 1012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.