Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL15845959 | 0.95 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL4748243 | 0.95 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL1146 | 0.95 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL434089 | 0.95 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| SCHEMBL23528233 | 0.91 | MAPT (0.46) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL5862137 | 0.91 | MAPT (0.44) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL9716114 | 0.91 | TSHR (0.46) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL565435 | 0.91 | MAPT (0.44) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL5934922 | 0.91 | MAPT (0.44) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| SCHEMBL2157617 | 0.91 | MAPT (0.46) | MAPTKDM4ESMN1; SMN2ALOX15HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642975-B1 | SKIN EXTERNAL PREPARATION AND METHOD OF PRODUCING SAME | SHOWA DENKO KK (JP) | 2016-08-24 | — | — | EP | disclosed |
| US-9180079-B2 | Skin external preparation and method of producing same | SHOWA DENKO K.K. (JP) | 2015-11-10 | — | — | US | disclosed |
| EP-2514405-B1 | Silicone Microemulsion Composition | SHINETSU CHEMICAL CO (JP) | 2014-01-22 | — | — | EP | disclosed |
| US-20130287718-A1 | SKIN EXTERNAL PREPARATION AND METHOD OF PRODUCING SAME | SHOWA DENKO K.K. (JP) | 2013-10-31 | — | — | US | disclosed |
| EP-2642975-A2 | SKIN EXTERNAL PREPARATION AND METHOD OF PRODUCING SAME | Showa Denko K.K. (JP) | 2013-10-02 | — | — | EP | disclosed |
| EP-1541633-B1 | AQUEOUS SUSPENSION OF CROSSLINKED SILICONE PARTICLES, AQUEOUS EMULSION OF OIL CONTAINING CROSSLINKED SILICONE PARTICLES, AND COSMETIC INGREDIENTS | DOW CORNING TORAY CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-8329816-B2 | Silicone microemulsion composition | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2012-12-11 | — | — | US | disclosed |
| WO-2012153825-A2 | SKIN EXTERNAL PREPARATION AND METHOD OF PRODUCING SAME | SHOWA DENKO K.K. (JP) | 2012-11-15 | — | — | WO | disclosed |
| US-20120270985-A1 | SILICONE MICROEMULSION COMPOSITION | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2012-10-25 | — | — | US | disclosed |
| EP-2514405-A1 | Silicone Microemulsion Composition | Shin-Etsu Chemical Co., Ltd. (JP) | 2012-10-24 | — | — | EP | disclosed |
| CN-101378747-A | Whitening dermatological preparations | SHOWA DENKO KK (JP) | 2009-03-04 | — | — | CN | disclosed |
| EP-1858982-B1 | SILICONE EMULSION, METHOD OF PREPARING SAME, AND COSMETIC INGREDIENT | DOW CORNING (US) | 2008-08-27 | — | — | EP | disclosed |
| US-20080182833-A1 | Silicone Emulsion, Method of Preparing Same, and Cosmetic Ingredient | DOW CORNING CORPORATION | 2008-07-31 | — | — | US | disclosed |
| EP-1858982-A1 | SILICONE EMULSION, METHOD OF PREPARING SAME, AND COSMETIC INGREDIENT | Dow Corning Corporation (US) | 2007-11-28 | — | — | EP | disclosed |
| US-7300648-B2 | Polyorganosiloxane emulsion composition and a cosmetic material made therefrom | DOWECORNING TORAY SILICONE, CO., LTD. (JP) | 2007-11-27 | — | — | US | disclosed |
| WO-2006102010-A1 | SILICONE EMULSION, METHOD OF PREPARING SAME, AND COSMETIC INGREDIENT | DOW CORNING CORPORATION (US) | 2006-09-28 | — | — | WO | disclosed |
| US-20060127338-A1 | Aqueous suspensions of cross-linked silicone particles, aqueous emulsions of oil containing cross-linked silicone particles, and cosmetic raw material | DOW CORNING TORAY COMPANY, LTD. (JP) | 2006-06-15 | — | — | US | disclosed |
| EP-1541633-A1 | AQUEOUS SUSPENSION OF CROSSLINKED SILICONE PARTICLES, AQUEOUS EMULSION OF OIL CONTAINING CROSSLINKED SILICONE PARTICLES, AND COSMETIC INGREDIENTS | Dow Corning Toray Silicone Company, Ltd. (JP) | 2005-06-15 | — | — | EP | disclosed |
| US-20040138373-A1 | Polyorganosiloxane emulsion composition and a cosmetic material made therefrom | DOW TORAY CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| US-4071487-A | Anti-settling agents for pigmented aqueous lacquer and process for the manufacture of said agents | HENKEL KGAA (DT) | 1978-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060127338-A1 | Aqueous suspensions of cross-linked silicone particles, aqueous emulsions of oil containing cross-linked silicone particles, and cosmetic raw material | H1-0, CD44, H1-2 | MAPT 69/4885KDM4E 3966/4885SMN1; SMN2 182/4885 |
| US-20130287718-A1 | SKIN EXTERNAL PREPARATION AND METHOD OF PRODUCING SAME | RBP4, RBP1, PROC | MAPT 4355/4885KDM4E 4014/4885SMN1; SMN2 2725/4885 |
| US-20080182833-A1 | Silicone Emulsion, Method of Preparing Same, and Cosmetic Ingredient | SQLE, CUTA, SMOX | MAPT 3009/4885KDM4E 4047/4885SMN1; SMN2 2819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.