Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.69 |
| ▸ | NCF1 | P14598 | 4/20 | 0.49 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30438659 | 1.00 | ALOX15 (0.69) | ALOX15NCF1P2RY12ALDH1A1HPGD | |
| SCHEMBL30438115 | 0.86 | ALOX15 (0.64) | ALOX15NCF1P2RY12ALDH1A1HPGD | |
| SCHEMBL31389263 | 0.85 | ALOX15 (0.59) | ALOX15NCF1ALDH1A1HPGDKDM4E | |
| SCHEMBL9384536 | 0.84 | ALOX15 (0.62) | ALOX15NCF1P2RY12ALDH1A1HPGD | |
| SCHEMBL18528819 | 0.84 | ALOX15 (0.70) | ALOX15NCF1P2RY12ALDH1A1HPGD | |
| SCHEMBL31389285 | 0.84 | ALOX15 (0.70) | ALOX15NCF1P2RY12ALDH1A1HPGD | |
| SCHEMBL31389295 | 0.83 | ALOX15 (0.61) | ALOX15NCF1P2RY12ALDH1A1HPGD | |
| SCHEMBL9385188 | 0.83 | ALOX15 (0.61) | ALOX15NCF1P2RY12TSHR | |
| SCHEMBL90018 | 0.83 | ALOX15 (0.53) | ALOX15NCF1P2RY12ALDH1A1HPGD | |
| SCHEMBL297225 | 0.82 | ALOX15 (1.00) | ALOX15P2RY12ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10849881-B2 | Octahydro-cyclobuta[1,2-c;3,4-c′]dipyrrol-2-yl | HOFFMANN-LA ROCHE INC. (US) | 2020-12-01 | — | — | US | disclosed |
| US-20180280352-A1 | OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL | HOFFMANN-LA ROCHE INC. (US) | 2018-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180280352-A1 | OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL | NPY1R, NPY2R, DECR1 | ALOX15 1905/4885NCF1 3419/4885P2RY12 2685/4885 |
| US-10849881-B2 | Octahydro-cyclobuta[1,2-c;3,4-c′]dipyrrol-2-yl | NPY1R, NPY2R, DECR1 | ALOX15 1933/4885NCF1 3432/4885P2RY12 2618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.