Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | GLA | P06280 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20516437 | 0.98 | HPGD (0.58) | HPGDGLANPC1L3MBTL3L3MBTL1 | |
| SCHEMBL29486100 | 0.86 | GAA (0.52) | NPC1LMNAGAAALDH1A1KDM4E | |
| SCHEMBL28746378 | 0.86 | GAA (0.52) | NPC1LMNAGAAALDH1A1KDM4E | |
| SCHEMBL4163170 | 0.82 | L3MBTL3 (0.71) | HPGDNPC1L3MBTL3L3MBTL1LMNA | |
| SCHEMBL29944015 | 0.81 | HPGD (0.67) | HPGDGLANPC1GAAKDM4E | |
| SCHEMBL3455048 | 0.81 | L3MBTL3 (0.69) | HPGDNPC1L3MBTL3L3MBTL1LMNA | |
| SCHEMBL24883963 | 0.80 | P2RX7 (0.63) | HPGDGLANPC1GAAALDH1A1 | |
| SCHEMBL16344196 | 0.80 | GAA (0.59) | HPGDGLANPC1L3MBTL3L3MBTL1 | |
| SCHEMBL24135017 | 0.80 | MAPK1 (0.51) | L3MBTL1LMNAGAAALDH1A1TSHR | |
| SCHEMBL24135015 | 0.79 | GABRD (0.52) | ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10336709-B2 | Lp-PLA2 inhibitors | ABIDE THERAPEUTICS, INC (US) | 2019-07-02 | — | — | US | disclosed |
| US-10336709-B2 | Lp-PLA2 inhibitors | ABIDE THERAPEUTICS, INC (US) | 2019-07-02 | — | — | US | disclosed |
| US-20180282288-A1 | LP-PLA2 INHIBITORS | H. LUNDBECK A/S (DK) | 2018-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180282288-A1 | LP-PLA2 INHIBITORS | PLA2G12A, PLA2G12B, PLA2G4B | HPGD 565/4885GLA 370/4885NPC1 367/4885 |
| US-10336709-B2 | Lp-PLA2 inhibitors | PLA2G12A, PLA2G12B, PLA2G1B | HPGD 578/4885GLA 340/4885NPC1 413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.