SCHEMBL20522282

SCHEMBL20522282

COc1ccc(-c2ccccc2Nc2ccc(-c3nnc(NC(C)=O)s3)cc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 7/20 0.57
MAPT P10636 6/20 0.57
NPC1 O15118 5/20 0.57
KDM4E B2RXH2 5/20 0.57
KMT2A Q03164 5/20 0.57
ALDH1A1 P00352 3/20 0.55
SMN1; SMN2 Q16637 3/20 0.55
HPGD P15428 2/20 0.55
TP53 P04637 2/20 0.55
CYP1A2 P05177 1/20 0.55
AHR P35869 1/20 0.55
HSD17B10 Q99714 1/20 0.55
MEN1 O00255 4/20 0.55
RXFP1 Q9HBX9 1/20 0.55
DDX3X O00571 4/20 0.54
POLB P06746 1/20 0.53
MAPK1 P28482 1/20 0.53
HTT P42858 1/20 0.53
TDP1 Q9NUW8 1/20 0.52
CSNK2A2 P19784 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28348731 0.95 RAB9A (0.52) RAB9AMAPTNPC1KDM4EKMT2A
SCHEMBL20522371 0.91 CSNK2A2 (0.51) RAB9AMAPTNPC1KDM4EKMT2A
SCHEMBL20522356 0.89 RAB9A (0.47) RAB9AMAPTNPC1KDM4EKMT2A
SCHEMBL22712386 0.87 XIAP (0.53) RAB9AMAPTNPC1KDM4EKMT2A
SCHEMBL22712385 0.87 SMN1; SMN2 (0.53) RAB9AMAPTNPC1KDM4EKMT2A
SCHEMBL20522354 0.87 KDM4E (0.57) RAB9AMAPTNPC1KDM4EKMT2A
SCHEMBL20522279 0.87 RAB9A (0.58) RAB9AMAPTNPC1KDM4EKMT2A
SCHEMBL28348979 0.86 CSNK2A2 (0.47) RAB9AMAPTNPC1KDM4EKMT2A
SCHEMBL28348729 0.85 HDAC1 (0.57) RAB9AMAPTNPC1KDM4EKMT2A
SCHEMBL20522352 0.85 RAB9A (0.54) RAB9AMAPTNPC1KDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260001873-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2026-01-01 US disclosed
US-12384772-B2 Inhibitors VIVORYON THERAPEUTICS N.V. (DE) 2025-08-12 US disclosed
CN-117024352-A Novel inhibitors 维沃里翁治疗股份有限公司 2023-11-10 CN disclosed
US-20220274977-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2022-09-01 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
EP-3601269-A1 NOVEL INHIBITORS Probiodrug AG (DE) 2020-02-05 EP disclosed
WO-2018178384-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2018-10-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260001873-A1 NOVEL INHIBITORS GLS, GLS2, SULT1E1 RAB9A 838/4885MAPT 3890/4885NPC1 3535/4885
US-20200377493-A1 NOVEL INHIBITORS GLUL, GLS, QPCT RAB9A 3346/4885MAPT 2845/4885NPC1 4774/4885
US-11339152-B2 Inhibitors GLUL, QPCT, GLS RAB9A 3332/4885MAPT 2831/4885NPC1 4800/4885
US-12384772-B2 Inhibitors GLS, QPCT, GLS2 RAB9A 1349/4885MAPT 1850/4885NPC1 4752/4885
US-20220274977-A1 NOVEL INHIBITORS GLUL, GLS, QPCT RAB9A 3514/4885MAPT 3042/4885NPC1 4709/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.