SCHEMBL20522279

SCHEMBL20522279

COc1ccc(-c2cnccc2Nc2ccc(-c3nnc(NC(C)=O)s3)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 7/20 0.58
KDM4E B2RXH2 7/20 0.58
MAPT P10636 4/20 0.58
KMT2A Q03164 3/20 0.58
MEN1 O00255 2/20 0.58
POLB P06746 2/20 0.58
MAPK1 P28482 1/20 0.58
HTT P42858 1/20 0.58
NPC1 O15118 5/20 0.54
CSNK2A2 P19784 2/20 0.48
CSNK2A1 P68400 2/20 0.48
PDE10A Q9Y233 1/20 0.48
DYRK1A Q13627 2/20 0.48
ALDH1A1 P00352 4/20 0.47
HPGD P15428 3/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
DDX3X O00571 2/20 0.47
TDP1 Q9NUW8 1/20 0.47
RXFP1 Q9HBX9 1/20 0.47
GAA P10253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28348669 0.95 RAB9A (0.53) RAB9AKDM4EMAPTKMT2AMEN1
SCHEMBL20522361 0.87 KDM4E (0.49) RAB9AKDM4EMAPTKMT2AMEN1
SCHEMBL20522282 0.87 RAB9A (0.57) RAB9AKDM4EMAPTKMT2AMEN1
SCHEMBL28348666 0.86 HDAC1 (0.55) RAB9AKDM4EMAPTKMT2AMEN1
SCHEMBL28352566 0.84 BLM (0.46) RAB9AKDM4EMAPTKMT2AMEN1
SCHEMBL28348731 0.82 RAB9A (0.52) RAB9AKDM4EMAPTKMT2AMEN1
SCHEMBL20522383 0.82 KDM4E (0.60) RAB9AKDM4EMAPTKMT2AMEN1
SCHEMBL20522352 0.80 RAB9A (0.54) RAB9AKDM4EMAPTKMT2AMEN1
SCHEMBL30610417 0.80 RAB9A (0.54) RAB9AKDM4EMAPTKMT2AMEN1
SCHEMBL20522371 0.78 CSNK2A2 (0.51) RAB9AKDM4EMAPTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260001873-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2026-01-01 US disclosed
US-12384772-B2 Inhibitors VIVORYON THERAPEUTICS N.V. (DE) 2025-08-12 US disclosed
CN-117024352-A Novel inhibitors 维沃里翁治疗股份有限公司 2023-11-10 CN disclosed
US-20220274977-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2022-09-01 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
EP-3601269-A1 NOVEL INHIBITORS Probiodrug AG (DE) 2020-02-05 EP disclosed
WO-2018178384-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2018-10-04 WO disclosed
US-9291901-B2 Amine treated maleic anhydride polymers with pendent silyl group, compositions and applications thereof SUMITOMO BAKELITE CO., LTD. (JP) 2016-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260001873-A1 NOVEL INHIBITORS GLS, GLS2, SULT1E1 RAB9A 838/4885KDM4E 1773/4885MAPT 3890/4885
US-20200377493-A1 NOVEL INHIBITORS GLUL, GLS, QPCT RAB9A 3346/4885KDM4E 1119/4885MAPT 2845/4885
US-11339152-B2 Inhibitors GLUL, QPCT, GLS RAB9A 3332/4885KDM4E 1078/4885MAPT 2831/4885
US-12384772-B2 Inhibitors GLS, QPCT, GLS2 RAB9A 1349/4885KDM4E 1254/4885MAPT 1850/4885
US-20220274977-A1 NOVEL INHIBITORS GLUL, GLS, QPCT RAB9A 3514/4885KDM4E 1160/4885MAPT 3042/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.