Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.33 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.33 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452406 | 0.83 | TUBB4A (0.38) | ALDH1A1KDM4EPTGS2RAB9ACYP2A6 | |
| SCHEMBL22604902 | 0.79 | TUBB4A (0.41) | SLC6A3ALDH1A1KDM4EPTGS2RAB9A | |
| SCHEMBL22604964 | 0.79 | ALDH1A1 (0.40) | ALDH1A1KDM4EPTGS2RAB9ACYP2A6 | |
| SCHEMBL18970011 | 0.75 | KDM4E (0.52) | ALDH1A1KDM4EPTGS2RAB9ACYP2A6 | |
| SCHEMBL28057799 | 0.75 | ALDH1A1 (0.37) | ALDH1A1KDM4EPTGS2RAB9ACYP2A6 | |
| SCHEMBL22452273 | 0.75 | TUBB4A (0.55) | ALDH1A1KDM4EPTGS2RAB9ACYP2A6 | |
| SCHEMBL31414002 | 0.75 | ALDH1A1 (0.56) | ALDH1A1KDM4ERAB9ATUBB4ATUBB | |
| SCHEMBL22604974 | 0.75 | KIF11 (0.41) | ALDH1A1KDM4EPTGS2RAB9ACYP2A6 | |
| SCHEMBL17490929 | 0.73 | F2R (0.36) | SLC6A3ALDH1A1KDM4EPTGS2RAB9A | |
| SCHEMBL13892816 | 0.73 | ALDH5A1 (0.53) | ALDH1A1KDM4EHPGDALDH5A1ABAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11617738-B2 | 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use | PURDUE RESEARCH FOUNDATION (US) | 2023-04-04 | — | — | US | disclosed |
| US-20210196684-A1 | 6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE | PURDUE RESEARCH FOUNDATION (US) | 2021-07-01 | — | — | US | disclosed |
| US-10980781-B2 | 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use | PURDUE RESEARCH FOUNDATION (US) | 2021-04-20 | — | — | US | disclosed |
| US-20200078336-A1 | 6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE | PURDUE RESEARCH FOUNDATION (US) | 2020-03-12 | — | — | US | disclosed |
| WO-2018183587-A1 | 6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE | PURDUE RESEARCH FOUNDATION (US) | 2018-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200078336-A1 | 6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE | USP7, USP3, USP2 | SLC6A3 4463/4885ALDH1A1 647/4885KDM4E 894/4885 |
| US-20210196684-A1 | 6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE | USP7, USP3, USP2 | SLC6A3 4463/4885ALDH1A1 647/4885KDM4E 894/4885 |
| US-10980781-B2 | 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use | USP7, USP3, USP2 | SLC6A3 4463/4885ALDH1A1 647/4885KDM4E 894/4885 |
| US-11617738-B2 | 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use | USP7, USP3, USP2 | SLC6A3 4463/4885ALDH1A1 647/4885KDM4E 894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.