Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | ESRRA | P11474 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20523653 | 0.86 | SLC22A12 (0.48) | NR3C1ALOX5APFEN1MCL1KDM4E | |
| SCHEMBL20523469 | 0.73 | FYN (0.50) | ALOX5APFEN1POLB | |
| SCHEMBL30016133 | 0.72 | PTPN1 (0.54) | HSD17B10LMNAPTPN1PTPN2PTPN6 | |
| SCHEMBL29134872 | 0.72 | PTPN1 (0.54) | HSD17B10LMNAPTPN1PTPN2PTPN6 | |
| SCHEMBL20523589 | 0.71 | ALDH1A1 (0.48) | LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL20523720 | 0.67 | KMT2A (0.43) | KDM4EALDH1A1 | |
| SCHEMBL20523546 | 0.66 | NR3C1 (0.41) | NR3C1KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL4667179 | 0.64 | MCL1 (0.61) | LMNAALOX5APFEN1MCL1TSHR | |
| SCHEMBL10094332 | 0.64 | L3MBTL1 (0.74) | HSD17B10LMNAALOX5APFEN1MCL1 | |
| SCHEMBL13848266 | 0.63 | L3MBTL1 (0.54) | NR3C1ALOX5APFEN1MCL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3600307-A1 | COMPOSITIONS FOR USE IN METHODS OF INHIBITING PROTEIN KINASES | University of Houston System (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183633-A1 | COMPOSITIONS FOR USE IN METHODS OF INHIBITING PROTEIN KINASES | UNIVERSITY OF HOUSTON SYSTEM (US) | 2018-10-04 | — | — | WO | disclosed |