Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20524364 | 0.87 | PRKAG1 (0.31) | — | |
| SCHEMBL29218326 | 0.70 | IRAK4 (0.35) | CFTR | |
| SCHEMBL27248736 | 0.67 | GHSR (0.31) | CFTR | |
| SCHEMBL21001854 | 0.67 | MAPK8 (0.30) | MAPK8MAPK9MAPK10 | |
| SCHEMBL3469250 | 0.67 | MAPK8 (0.30) | MAPK8MAPK9MAPK10 | |
| SCHEMBL17713790 | 0.67 | PRKAG1 (0.31) | — | |
| SCHEMBL28881758 | 0.66 | ALDH1A1 (0.31) | — | |
| SCHEMBL17020281 | 0.66 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3CHRM2CHRM4 | |
| SCHEMBL17008339 | 0.66 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3CHRM2CHRM4 | |
| SCHEMBL20524328 | 0.66 | KDM4E (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601284-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | H. Hoffnabb-La Roche Ag (CH) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183956-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2018-10-04 | — | — | WO | disclosed |