Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 8/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL709690 | 0.84 | MAPT (0.49) | L3MBTL1ALDH1A1LMNASLC6A9SLC6A5 | |
| SCHEMBL4147771 | 0.83 | SLC6A9 (0.56) | L3MBTL1ALDH1A1LMNASLC6A9SLC6A5 | |
| SCHEMBL532719 | 0.83 | HTT (0.49) | POLBALDH1A1LMNASLC6A9SLC6A5 | |
| SCHEMBL13156287 | 0.82 | GPR119 (0.54) | ALDH1A1LMNAMAPT | |
| SCHEMBL30062534 | 0.82 | GPR119 (0.54) | ALDH1A1LMNAMAPT | |
| SCHEMBL17240307 | 0.80 | KDM4E (0.50) | KDM4EGAAHSD17B10POLBTDP1 | |
| SCHEMBL31491403 | 0.80 | KDM4E (0.50) | KDM4EGAAHSD17B10POLBTDP1 | |
| SCHEMBL631389 | 0.80 | RBP4 (0.50) | LMNASLC6A9SLC6A5SMN1; SMN2MAPT | |
| SCHEMBL26143927 | 0.79 | ALDH1A1 (0.59) | KDM4EGAAHSD17B10POLBL3MBTL1 | |
| SCHEMBL20524553 | 0.79 | MAPT (0.57) | GAATDP1L3MBTL1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3600312-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | Takeda Pharmaceutical Company Limited (JP) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183145-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-10-04 | — | — | WO | disclosed |