Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | HTR6 | P50406 | 4/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.33 |
| ▸ | AKT2 | P31751 | 3/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | OGA | O60502 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525329 | 0.87 | GHSR (0.43) | — | |
| SCHEMBL20525382 | 0.85 | CYP1A2 (0.38) | DRD2HTR6 | |
| SCHEMBL20525472 | 0.85 | CYP3A4 (0.40) | MEN1 | |
| SCHEMBL16804333 | 0.85 | KDM1A (0.36) | DRD2HTR6GRM2AKT2AKT1 | |
| SCHEMBL20525417 | 0.85 | FGFR1 (0.32) | FGFR1FGFR4SIRT2SIRT1SIRT3 | |
| SCHEMBL20525408 | 0.83 | FAAH (0.38) | DRD2HTR6 | |
| SCHEMBL20525461 | 0.82 | DGAT1 (0.38) | GRM2OGAFGFR1FGFR4CNR2 | |
| SCHEMBL20525436 | 0.82 | FGFR1 (0.32) | GRM2FGFR1FGFR4 | |
| SCHEMBL16804212 | 0.81 | OPRD1 (0.39) | MEN1 | |
| SCHEMBL16804290 | 0.81 | HDAC6 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080125-B1 | NOVEL AZAINDOLE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE (HDAC) INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2018-10-10 | — | — | EP | disclosed |