Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525605 | 0.86 | DRD2 (0.43) | MAPTLMNAALDH1A1HTTSIGMAR1 | |
| SCHEMBL20525642 | 0.85 | ACHE (0.42) | ALKACHEKDM4EALDH1A1POLB | |
| SCHEMBL371832 | 0.82 | ACHE (0.60) | MAPTACHEBACE1 | |
| SCHEMBL20525735 | 0.77 | MET (0.39) | CCNCCDK8MEN1KMT2A | |
| SCHEMBL20525842 | 0.75 | MET (0.37) | MAPTTSHRALDH1A1POLBCCNC | |
| SCHEMBL2876304 | 0.75 | SIGMAR1 (0.72) | MAPTLMNAMAPK1L3MBTL1TSHR | |
| SCHEMBL11923385 | 0.73 | SIGMAR1 (0.79) | MAPTLMNAMAPK1L3MBTL1TSHR | |
| SCHEMBL6160982 | 0.73 | LMNA (0.70) | MAPTLMNATSHRKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11213408 | 0.72 | SIGMAR1 (0.77) | MAPTLMNAMAPK1L3MBTL1TSHR | |
| SCHEMBL20525677 | 0.72 | MET (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |