SCHEMBL20528890

SCHEMBL20528890

Cc1cc(NCc2ccncc2)n2nc(C)c(-c3ccc4c(c3)c(C)nn4C)c2n1

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PI4KB Q9UBF8 7/20 0.60
ALDH1A1 P00352 8/20 0.50
KDM4E B2RXH2 8/20 0.50
MAPT P10636 6/20 0.50
NPSR1 Q6W5P4 4/20 0.49
RAB9A P51151 3/20 0.49
TDP1 Q9NUW8 3/20 0.49
MAPK1 P28482 3/20 0.49
HPGD P15428 6/20 0.47
LMNA P02545 3/20 0.47
HTT P42858 2/20 0.47
USP2 O75604 2/20 0.46
HSD17B10 Q99714 2/20 0.46
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
TSHR P16473 1/20 0.42
NPC1 O15118 1/20 0.42
ATM Q13315 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29644477 1.00 PI4KB (0.60) PI4KBALDH1A1KDM4EMAPTNPSR1
SCHEMBL21628162 0.91 PI4KB (0.73) PI4KBALDH1A1KDM4EMAPTNPSR1
SCHEMBL29715021 0.90 PI4KB (0.62) PI4KBALDH1A1KDM4EMAPTNPSR1
SCHEMBL23024624 0.90 PI4KB (0.62) PI4KBALDH1A1KDM4EMAPTNPSR1
SCHEMBL21628158 0.89 PI4KB (0.59) PI4KBALDH1A1KDM4EMAPTNPSR1
SCHEMBL21628159 0.89 PI4KB (0.59) PI4KBALDH1A1KDM4EMAPTNPSR1
SCHEMBL23012288 0.88 PI4KB (0.53) PI4KBALDH1A1KDM4EMAPTNPSR1
SCHEMBL29715034 0.88 PI4KB (0.53) PI4KBALDH1A1KDM4EMAPTNPSR1
SCHEMBL23024619 0.88 PI4KB (0.53) PI4KBALDH1A1KDM4EMAPTNPSR1
SCHEMBL29714989 0.88 PI4KB (0.53) PI4KBALDH1A1KDM4EMAPTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4028131-B1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2023-11-22 EP claimed
EP-4028131-A1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2022-07-20 EP claimed
EP-3606926-B1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2021-05-26 EP claimed
WO-2021032611-A1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2021-02-25 WO claimed
EP-3606926-A1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2020-02-12 EP claimed
US-20200031833-A1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2020-01-30 US claimed
WO-2018185120-A1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2018-10-11 WO claimed
US-12319696-B2 2,6-dimethyl-n-((pyridin-4-yl)methyl)imidazo[1,2-b]pyridazin-8-amine and 2,5-dimethyl-n-[(pyridin-4-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine derivatives for treating viral infections CUROVIR AB (SE) 2025-06-03 US disclosed
EP-4028131-B1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2023-11-22 EP disclosed
EP-4028131-B1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2023-11-22 EP disclosed
EP-3864017-B1 2,6-DIMETHYL-N-((PYRIDIN-4-YL)METHYL)IMIDAZO[1,2-B]PYRIDAZIN-8-AMINE AND 2,5-DIMETHYL-N-[(PYRIDIN-4-YL)METHYL]PYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE DERIVATIVES FOR TREATING VIRAL INFECTIONS CUROVIR AB (SE) 2023-07-26 EP disclosed
EP-3864017-B1 2,6-DIMETHYL-N-((PYRIDIN-4-YL)METHYL)IMIDAZO[1,2-B]PYRIDAZIN-8-AMINE AND 2,5-DIMETHYL-N-[(PYRIDIN-4-YL)METHYL]PYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE DERIVATIVES FOR TREATING VIRAL INFECTIONS CUROVIR AB (SE) 2023-07-26 EP disclosed
US-20210340147-A1 2,6-DIMETHYL-N-((PYRIDlN-4-YL)METHYL)IMIDAZO[1,2-B]PYRIDAZIN-8-AMINE AND 2,5-DIMETHYL-N-[(PYRIDlN-4-YL)METHYL]PYRAZOLO[1,5-A]PYRIMIDlN-7-AMINE DERIVATIVES FOR TREATING VIRAL INFECTIONS CUROVIR AB (SE) 2021-11-04 US disclosed
EP-3606926-B1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2021-05-26 EP disclosed
EP-3606926-B1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2021-05-26 EP disclosed
US-11001587-B2 Substituted indazoles as phosphatidylinositol kinase inhibitors CUROVIR AB (SE) 2021-05-11 US disclosed
US-11001587-B2 Substituted indazoles as phosphatidylinositol kinase inhibitors CUROVIR AB (SE) 2021-05-11 US disclosed
WO-2021032611-A1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2021-02-25 WO disclosed
US-20200031833-A1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2020-01-30 US disclosed
US-20200031833-A1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2020-01-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12319696-B2 2,6-dimethyl-n-((pyridin-4-yl)methyl)imidazo[1,2-b]pyridazin-8-amine and 2,5-dimethyl-n-[(pyridin-4-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine derivatives for treating viral infections ZC3HAV1, IFNAR1, ZYX PI4KB 821/4885ALDH1A1 2692/4885KDM4E 182/4885
US-11001587-B2 Substituted indazoles as phosphatidylinositol kinase inhibitors PIKFYVE, PI4KA, PIP4K2B PI4KB 6/4885ALDH1A1 4239/4885KDM4E 3032/4885
US-20210340147-A1 2,6-DIMETHYL-N-((PYRIDlN-4-YL)METHYL)IMIDAZO[1,2-B]PYRIDAZIN-8-AMINE AND 2,5-DIMETHYL-N-[(PYRIDlN-4-YL)METHYL]PYRAZOLO[1,5-A]PYRIMIDlN-7-AMINE DERIVATIVES FOR TREATING VIRAL INFECTIONS NSUN2, EIF2AK2, METTL16 PI4KB 482/4885ALDH1A1 2623/4885KDM4E 318/4885
US-20200031833-A1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY BECN1, SQSTM1, TFEB PI4KB 630/4885ALDH1A1 1445/4885KDM4E 4130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.