SCHEMBL21628159

SCHEMBL21628159

Cc1cc(NCc2ccc(Cl)cc2)n2nc(C)c(-c3ccc4c(c3)c(C)nn4C)c2n1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PI4KB Q9UBF8 5/20 0.59
ALDH1A1 P00352 9/20 0.58
MAPT P10636 7/20 0.58
KDM4E B2RXH2 5/20 0.58
NPSR1 Q6W5P4 2/20 0.58
MAPK1 P28482 1/20 0.58
RAB9A P51151 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
HPGD P15428 6/20 0.56
USP2 O75604 1/20 0.56
HSD17B10 Q99714 1/20 0.56
MEN1 O00255 4/20 0.54
KMT2A Q03164 4/20 0.54
HTT P42858 2/20 0.52
LMNA P02545 1/20 0.52
POLB P06746 1/20 0.47
ATM Q13315 1/20 0.47
CRHR1 P34998 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21628158 0.90 PI4KB (0.59) PI4KBALDH1A1MAPTKDM4ENPSR1
SCHEMBL21628162 0.90 PI4KB (0.73) PI4KBALDH1A1MAPTKDM4ENPSR1
SCHEMBL20528890 0.89 PI4KB (0.60) PI4KBALDH1A1MAPTKDM4ENPSR1
SCHEMBL29644477 0.89 PI4KB (0.60) PI4KBALDH1A1MAPTKDM4ENPSR1
SCHEMBL29644495 0.89 PI4KB (0.57) PI4KBALDH1A1MAPTKDM4ENPSR1
SCHEMBL20529103 0.89 PI4KB (0.57) PI4KBALDH1A1MAPTKDM4ENPSR1
SCHEMBL23387092 0.88 PI4KB (0.56) PI4KBALDH1A1MAPTKDM4ENPSR1
SCHEMBL29644425 0.88 PI4KB (0.55) PI4KBALDH1A1MAPTKDM4ENPSR1
SCHEMBL20529179 0.88 PI4KB (0.55) PI4KBALDH1A1MAPTKDM4ENPSR1
SCHEMBL20528876 0.87 PI4KB (0.57) PI4KBALDH1A1MAPTKDM4ENPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4676485-A1 COMPOUND AND FORMULATION FOR SYSTEMIC THERAPY BY ORAL TRANSMUCOSAL ADMINISTRATION CUROVIR AB (SE) 2026-01-14 EP claimed
WO-2024184442-A1 COMPOUND AND FORMULATION FOR SYSTEMIC THERAPY BY ORAL TRANSMUCOSAL ADMINISTRATION CUROVIR AB (SE) 2024-09-12 WO claimed
EP-4028131-B1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2023-11-22 EP claimed
EP-3606926-B1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2021-05-26 EP claimed
US-20200031833-A1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2020-01-30 US claimed
EP-4676485-A1 COMPOUND AND FORMULATION FOR SYSTEMIC THERAPY BY ORAL TRANSMUCOSAL ADMINISTRATION CUROVIR AB (SE) 2026-01-14 EP disclosed
WO-2024184442-A1 COMPOUND AND FORMULATION FOR SYSTEMIC THERAPY BY ORAL TRANSMUCOSAL ADMINISTRATION CUROVIR AB (SE) 2024-09-12 WO disclosed
EP-4028131-B1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2023-11-22 EP disclosed
EP-4028131-B1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2023-11-22 EP disclosed
EP-3606926-B1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2021-05-26 EP disclosed
EP-3606926-B1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2021-05-26 EP disclosed
US-11001587-B2 Substituted indazoles as phosphatidylinositol kinase inhibitors CUROVIR AB (SE) 2021-05-11 US disclosed
US-11001587-B2 Substituted indazoles as phosphatidylinositol kinase inhibitors CUROVIR AB (SE) 2021-05-11 US disclosed
WO-2021032611-A1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2021-02-25 WO disclosed
US-20200031833-A1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2020-01-30 US disclosed
US-20200031833-A1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY CUROVIR AB (SE) 2020-01-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11001587-B2 Substituted indazoles as phosphatidylinositol kinase inhibitors PIKFYVE, PI4KA, PIP4K2B PI4KB 6/4885ALDH1A1 4239/4885MAPT 503/4885
US-20200031833-A1 HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY BECN1, SQSTM1, TFEB PI4KB 630/4885ALDH1A1 1445/4885MAPT 86/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.