Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.44 |
| ▸ | ATR | Q13535 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530352 | 0.88 | HDAC6 (0.41) | MAPTMAP4K4ATRMEN1KMT2A | |
| SCHEMBL20530333 | 0.87 | MET (0.46) | TP53MAPTMAP4K4MEN1KMT2A | |
| SCHEMBL1330756 | 0.86 | MET (0.51) | TP53MAPTMAP4K4HPGDSMEN1 | |
| SCHEMBL1330028 | 0.85 | MET (0.52) | TP53MAPTMAP4K4HPGDSMEN1 | |
| SCHEMBL20530297 | 0.85 | MKNK1 (0.46) | TP53MAP4K4PARP1BRAF | |
| SCHEMBL20530292 | 0.84 | MET (0.51) | TP53MAPTMAP4K4MEN1KMT2A | |
| SCHEMBL20530324 | 0.83 | L3MBTL1 (0.52) | TP53MAPTMAP4K4 | |
| SCHEMBL20530341 | 0.83 | HDAC6 (0.43) | TP53MAPTMAP4K4KMT2A | |
| SCHEMBL20530355 | 0.83 | RIPK1 (0.43) | TP53MAPTKMT2A | |
| SCHEMBL20530329 | 0.81 | MKNK1 (0.40) | TP53HPGDSMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571878-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | INCOZEN THERAPEUTICS PVT LTD (IN) | 2018-10-17 | — | — | EP | claimed |