Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 12/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530311 | 0.92 | GPR119 (0.40) | METADORA2AADORA1KDRMEN1 | |
| SCHEMBL20530346 | 0.90 | POLB (0.38) | METADORA2AADORA1KDRMEN1 | |
| SCHEMBL20530349 | 0.90 | MET (0.48) | METADORA2AADORA1CDKL5 | |
| SCHEMBL20530288 | 0.90 | HPGD (0.46) | METMEN1KMT2A | |
| SCHEMBL20530328 | 0.89 | MKNK2 (0.39) | METADORA2AADORA1MEN1KMT2A | |
| SCHEMBL22729926 | 0.87 | MET (0.36) | METADORA2AADORA1KDRMEN1 | |
| SCHEMBL20530364 | 0.87 | MAP4K4 (0.47) | METMEN1KMT2ASLC22A12 | |
| SCHEMBL22729945 | 0.87 | MET (0.36) | METADORA2AADORA1KDRMEN1 | |
| SCHEMBL22729947 | 0.87 | MET (0.36) | METADORA2AADORA1KDRMEN1 | |
| SCHEMBL20530341 | 0.86 | HDAC6 (0.43) | METADORA2AADORA1KDRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571878-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | INCOZEN THERAPEUTICS PVT LTD (IN) | 2018-10-17 | — | — | EP | claimed |