⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11257472 | 0.69 | TBXAS1 (0.32) | — | |
| SCHEMBL6044385 | 0.67 | TBXAS1 (0.33) | — | |
| SCHEMBL22750410 | 0.66 | CYP11B2 (0.38) | — | |
| Succinic Acid SCHEMBL27888588 | 0.63 | TBXAS1 (0.34) | — | |
| SCHEMBL7096286 | 0.60 | ALDH1A1 (0.38) | — | |
| SCHEMBL19152161 | 0.59 | PARP1 (0.36) | — | |
| SCHEMBL25280775 | 0.57 | — | — | |
| SCHEMBL27843880 | 0.56 | TSHR (0.32) | — | |
| SCHEMBL9639870 | 0.54 | — | — | |
| SCHEMBL14725981 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160289278-A1 | GENES OF AN OTITIS MEDIA ISOLATE OF NONTYPEABLE HEAMOPHILUS INFLUENZAE | NATIONWIDE CHILDREN'S HOSPITAL | 2016-10-06 | — | — | US | disclosed |
| US-20150218231-A1 | GENES OF AN OTITIS MEDIA ISOLATE OF NONTYPEABLE HEAMOPHILUS INFLUENZAE | NATIONWIDE CHILDREN'S HOSPITAL | 2015-08-06 | — | — | US | disclosed |
| US-9034642-B2 | Genes of an otitis media isolate of nontypeable Haemophilus influenzae | NATIONWIDE CHILDREN'S HOSPITAL (US) | 2015-05-19 | — | — | US | disclosed |
| US-20140127221-A1 | Genes of an Otitis Media Isolate of Nontypeable Haemophilus Influenzae | NATIONWIDE CHILDREN'S HOSPITAL, INC. (US) | 2014-05-08 | — | — | US | disclosed |
| US-8652773-B2 | Genes of an otitis media isolate of nontypeable Haemophilus influenza | NATIONWIDE CHILDREN'S HOSPITAL, INC. (US) | 2014-02-18 | — | — | US | disclosed |
| US-20130078254-A1 | GENES OF AN OTITIS MEDIA ISOLATE OF NONTYPEABLE HAEMOPHILUS INFLUENZAE | NATIONWIDE CHILDREN'S HOSPITAL, INC. (US) | 2013-03-28 | — | — | US | disclosed |
| US-8283114-B2 | Genes of an otitis media isolate of nontypeable Haemophilus influenzae | NATIONWIDE CHILDREN'S HOSPITAL, INC. (US) | 2012-10-09 | — | — | US | disclosed |
| EP-2343312-A1 | Genes of an otitis media isolate of nontypeable haemophilus influenzae | Nationwide Children's Hospital, Inc. (US) | 2011-07-13 | — | — | EP | disclosed |
| US-20110135646-A1 | Genes of an Otitis Media Isolate of Nontypeable Haemophilus influenzae | NATIONWIDE CHILDREN'S HOSPITAL, INC. (US) | 2011-06-09 | — | — | US | disclosed |
| EP-2070945-A1 | Genes of an otitis media isolate of nontypeable haemophilus influenzae | Nationwide Children's Hospital, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |