SCHEMBL2053480

SCHEMBL2053480

Fc1ccc(F)c(-c2[c]ccc(Cl)c2)c1

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CA3 P07451 1/20 0.33
CA6 P23280 1/20 0.33
CA5A P35218 1/20 0.33
CA9 Q16790 1/20 0.33
CA14 Q9ULX7 1/20 0.33
CA5B Q9Y2D0 1/20 0.33
PTPN1 P18031 1/20 0.33
TAS1R3 Q7RTX0 1/20 0.32
TAS1R1 Q7RTX1 1/20 0.32
TAS1R2 Q8TE23 1/20 0.32
SLC9A1 P19634 2/20 0.31
CES2 O00748 1/20 0.31
CES1 P23141 1/20 0.31
PDE2A O00408 1/20 0.30
PDE10A Q9Y233 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL434555 0.87 CNR1 (0.34) CA3CA6CA5ACA9CA14
SCHEMBL17514748 0.84 NISCH (0.41)
SCHEMBL432357 0.81 GABRP (0.41) PTPN1PDE2APDE10A
SCHEMBL2052904 0.81 MPL (0.35) CA3CA6CA5ACA9CA14
SCHEMBL2053522 0.80 ACHE (0.36) CA3CA6CA5ACA9CA14
SCHEMBL433550 0.79 KMO (0.36)
SCHEMBL1116582 0.77 GABRP (0.38)
SCHEMBL435603 0.76 KMO (0.35) TAS1R3TAS1R1TAS1R2
SCHEMBL5325455 0.76 PTPN1 (0.40) CA3CA6CA5ACA9CA14
SCHEMBL17514680 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013182433-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-12-12 WO disclosed
EP-2547687-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-01-23 EP disclosed
EP-2513067-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2012-10-24 EP disclosed
WO-2011113820-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2011-09-22 WO disclosed
WO-2011073145-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2011-06-23 WO disclosed