SCHEMBL2053522

SCHEMBL2053522

Cc1cc[c]c(-c2cc(F)ccc2F)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.36
TDP1 Q9NUW8 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
SLC9A1 P19634 2/20 0.34
S1PR2 O95136 1/20 0.33
S1PR4 O95977 1/20 0.33
CA3 P07451 1/20 0.32
CA6 P23280 1/20 0.32
CA5A P35218 1/20 0.32
CA9 Q16790 1/20 0.32
CA14 Q9ULX7 1/20 0.32
CA5B Q9Y2D0 1/20 0.32
NISCH Q9Y2I1 1/20 0.32
PTPN1 P18031 1/20 0.32
KIF11 P52732 2/20 0.31
NFE2L2 Q16236 1/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
THRB P10828 1/20 0.31
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2051071 0.86 ALDH1A1 (0.39) ACHESLC9A1KIF11NFE2L2MEN1
SCHEMBL2053480 0.80 CA3 (0.33) SLC9A1CA3CA6CA5ACA9
SCHEMBL2013259 0.80 GPR3 (0.39) ACHEL3MBTL1MEN1HPGDKMT2A
SCHEMBL2052904 0.76 MPL (0.35) CA3CA6CA5ACA9CA14
SCHEMBL1491043 0.76 ACHE (0.41) ACHENFE2L2MEN1ALDH1A1KMT2A
SCHEMBL5325455 0.74 PTPN1 (0.40) L3MBTL1SLC9A1S1PR2S1PR4CA3
SCHEMBL2053205 0.74 ACHE (0.35) ACHESLC9A1
SCHEMBL7049757 0.73 ACHE (0.38) ACHETDP1ALDH1A1THRB
SCHEMBL2434582 0.73 NFE2L2 (0.35) NFE2L2ALDH1A1
SCHEMBL2013006 0.72 ACHE (0.35) ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013182433-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-12-12 WO disclosed
EP-2547687-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-01-23 EP disclosed
EP-2513067-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2012-10-24 EP disclosed
WO-2011073145-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2011-06-23 WO disclosed