Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ERN1 | O75460 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535997 | 1.00 | GRIK1 (0.34) | GRIK1KDM4ESMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL23702352 | 0.84 | KDM4E (0.33) | GRIK1KDM4ESMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL23702353 | 0.84 | KDM4E (0.33) | GRIK1KDM4ESMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL29063087 | 0.83 | GPR183 (0.34) | GRIK1SMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL23148058 | 0.83 | SLC9A3 (0.36) | KDM4ESMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL28925997 | 0.83 | PKM (0.35) | SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL18990053 | 0.83 | ALDH1A1 (0.38) | SMN1; SMN2MEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL18990057 | 0.83 | ALDH1A1 (0.38) | SMN1; SMN2MEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL18990052 | 0.83 | ALDH1A1 (0.38) | SMN1; SMN2MEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL28463731 | 0.81 | GAA (0.38) | KDM4ESMN1; SMN2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | NAVITOR PHARMACEUTICALS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. | 2021-08-05 | — | — | US | disclosed |
| WO-2018191146-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | RHEB, KRAS, NRAS | GRIK1 4312/4885KDM4E 2462/4885SMN1; SMN2 4200/4885 |
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | RHEB, GDI2, KRAS | GRIK1 3361/4885KDM4E 3566/4885SMN1; SMN2 2458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.