Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8771367 | 0.79 | CYP1A1 (0.39) | SLC6A4SLC6A3SLC6A2KCNH2HTR2A | |
| SCHEMBL19808998 | 0.75 | FFAR1 (0.36) | SLC6A3RAPGEF4FFAR1FFAR4GRM5 | |
| SCHEMBL19781334 | 0.74 | RAPGEF4 (0.33) | SLC6A4KCNH2HTR2ARAPGEF4FFAR1 | |
| SCHEMBL9472942 | 0.71 | CYP2A6 (0.41) | KCNH2FFAR1FFAR4 | |
| SCHEMBL19781335 | 0.70 | FFAR1 (0.31) | RAPGEF4FFAR1FFAR4GRM5 | |
| SCHEMBL30480935 | 0.70 | VCAM1 (0.48) | SLC6A4KCNH2HTR2A | |
| SCHEMBL234592 | 0.70 | VCAM1 (0.48) | SLC6A4KCNH2HTR2A | |
| SCHEMBL16955681 | 0.70 | RAPGEF4 (0.34) | SLC6A4SLC6A3SLC6A2RAPGEF4 | |
| SCHEMBL2552386 | 0.70 | SLC2A1 (0.35) | SLC6A4SLC6A3SLC6A2RAPGEF4FFAR1 | |
| SCHEMBL15094429 | 0.70 | EGFR (0.39) | SLC6A4SLC6A3SLC6A2RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3089788-B1 | SERINE/THREONINE KINASE INHIBITORS | GENENTECH INC (US) | 2018-10-24 | — | — | EP | claimed |